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Statins actually worsen Lp(a), do nothing to reduce particle number, it's debatale whether they reduce plaque and have a ton of deleterious side effects. The only benefit is reduction in inflammation and some anti-coagulant effects. Lowering LDL-C is not the issue. If I have to resort to pharma, there are much better drugs out now (i.e. PCSK9i, Nexleletol), but you're right; docs will dole them out like candy. But those docs aren't gurus. They are sick care docs practicing obsolete science.


1.5g extended-release niacin/day right now. I take taurine/curcumin as well, but I haven't seen any effect on lipids, though I see there is some science on it.


Genetic variants are what's left as the only factors that I can think of causing reistance to dietary/supplement/exercise intervention. That's where non-statin meds would have to play a part potentially. I still don't know how I affected that much of a drop in TC and trigs in just 30 days or so.


TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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