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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
HPTA Restart Plan 2022
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<blockquote data-quote="Cataceous" data-source="post: 223231" data-attributes="member: 38109"><p>By "nontrivial dose" I mean one that puts serum levels anywhere near the normal range. It's not well quantified that I know of, and probably varies quite a bit between individuals. Nonetheless, it has been shown that non-pulsatile delivery of testosterone is considerably more suppressive of the HPTA than natural pulsatile delivery. In other words, it takes less exogenous testosterone to exert negative feedback—suppression—on LH compared to what's produced naturally. An example made up purely for illustration: Ignoring diurnal variation, suppose a typical young guy has total testosterone of 700 ng/dL due to daily production of 7 mg of testosterone. This means that negative feedback on LH becomes significant around the serum level of 700 ng/dL. Now suppose you inject 4 mg of testosterone daily into this guy. You might well see complete suppression of LH and a serum level of only 400 ng/dL.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 223231, member: 38109"] By "nontrivial dose" I mean one that puts serum levels anywhere near the normal range. It's not well quantified that I know of, and probably varies quite a bit between individuals. Nonetheless, it has been shown that non-pulsatile delivery of testosterone is considerably more suppressive of the HPTA than natural pulsatile delivery. In other words, it takes less exogenous testosterone to exert negative feedback—suppression—on LH compared to what's produced naturally. An example made up purely for illustration: Ignoring diurnal variation, suppose a typical young guy has total testosterone of 700 ng/dL due to daily production of 7 mg of testosterone. This means that negative feedback on LH becomes significant around the serum level of 700 ng/dL. Now suppose you inject 4 mg of testosterone daily into this guy. You might well see complete suppression of LH and a serum level of only 400 ng/dL. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
HPTA Restart Plan 2022
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