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<blockquote data-quote="bfntn1" data-source="post: 103083" data-attributes="member: 18049"><p><img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite8" alt=":D" title="Big Grin :D" loading="lazy" data-shortname=":D" /> Thanks for that warm welcome!!!</p><p></p><p>I am definitely gonna check that out, have you looked into Dr Valter Longo's recent work? He has been experimenting with a Fasting Mimicking Diet. It causes [Apparently] the apoptosis of of Senescent cells and is followed by a period of feeding that causes the neogenesis of new cells and even apparently a proliferation of endogenous stem cells. It also reduces many inflammation markers across the board.</p><p></p><p>In many cases T1D rats began to develop B-cells and produce their own Insulin, though what is missing is any data concerning the pathogenesis of the disease after all T1D should honestly not be looked at as a disease but rather the symptom of a disease (as should any autoimmune disease) but either way the production of endogenous insulin in a T1D is a major breakthrough. </p><p></p><p>Interesting stuff</p><p></p><p>One of my own hypothesis concerning the pathogenesis of T1D is in relation to hormones it has often been noted that T1D on average have lower levels of Testosterone and also imbalances of GH and IGF1 as well as many other hormonal balances.</p><p></p><p>It is assumed in most research that the Diabetes is what causes the hormonal imbalance, but I think it would be interesting to consider that overall hormone imbalances in the body may not be caused by the metabolic disorder but potentially rather a cause of the disorder.</p><p></p><p>Just a hypothesis but one I would like to examine <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile :)" loading="lazy" data-shortname=":)" /></p><p></p><p>Anyway, I am gonna get that book now been thinking about what I would read next, and that does look stimulating.</p></blockquote><p></p>
[QUOTE="bfntn1, post: 103083, member: 18049"] :D Thanks for that warm welcome!!! I am definitely gonna check that out, have you looked into Dr Valter Longo's recent work? He has been experimenting with a Fasting Mimicking Diet. It causes [Apparently] the apoptosis of of Senescent cells and is followed by a period of feeding that causes the neogenesis of new cells and even apparently a proliferation of endogenous stem cells. It also reduces many inflammation markers across the board. In many cases T1D rats began to develop B-cells and produce their own Insulin, though what is missing is any data concerning the pathogenesis of the disease after all T1D should honestly not be looked at as a disease but rather the symptom of a disease (as should any autoimmune disease) but either way the production of endogenous insulin in a T1D is a major breakthrough. Interesting stuff One of my own hypothesis concerning the pathogenesis of T1D is in relation to hormones it has often been noted that T1D on average have lower levels of Testosterone and also imbalances of GH and IGF1 as well as many other hormonal balances. It is assumed in most research that the Diabetes is what causes the hormonal imbalance, but I think it would be interesting to consider that overall hormone imbalances in the body may not be caused by the metabolic disorder but potentially rather a cause of the disorder. Just a hypothesis but one I would like to examine :) Anyway, I am gonna get that book now been thinking about what I would read next, and that does look stimulating. [/QUOTE]
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