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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How to lower TRT weekly dosage safely?
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<blockquote data-quote="Cataceous" data-source="post: 213307" data-attributes="member: 38109"><p>Now try to find where that Pfizer figure came from. I sure couldn't.</p><p></p><p>I can't yet find the thread where [USER=13851]@madman[/USER] rounded up the best collection of evidence. But some indirect evidence is contained in <a href="https://www.excelmale.com/forum/threads/confused-about-testosterone-enanthate-half-life.17667/post-137255" target="_blank">this thread</a>. In that post Nelson gives the Nieschlag data with a half-life of 4.5 days for testosterone enanthate. Below that [USER=13851]@madman[/USER] <a href="https://www.excelmale.com/forum/threads/confused-about-testosterone-enanthate-half-life.17667/post-137292" target="_blank">includes a study</a> showing that cypionate and enanthate have very similar pharmacokinetics.</p><p></p><p>Also check out <a href="https://www.excelmale.com/forum/threads/is-the-feeling-of-well-being-on-trt-dosage-dependent.21477/post-184259" target="_blank">this post</a>, starting where he says "Cypionate study states the mean/median having a much shorter half-life." Studies showing a longer half-life failed to account for concurrent HPTA activity</p><p></p><p style="margin-left: 20px"><em><u>It is difficult to calculate the PK parameters of TC using traditional noncompartmental methods</u>, especially when the endogenous testosterone secretion rate is suppressed during the course of TC administration and the testosterone secretion rate is regulated by the LH-testosterone feedback loop system in HPG axis.</em> <u>Our estimated post hoc median tT half-life was 4.05 days, which is shorter than the mean reported elimination half-life of 6.9 days determined using noncompartmental analysis</u>.11 Such inconsistency is believed to result from failure to consider endogenous testosterone production. <u>When we assume endogenous testosterone secretion is 0 in the PPK analysis, the median estimated half-life increases to 6.87 days</u>.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 213307, member: 38109"] Now try to find where that Pfizer figure came from. I sure couldn't. I can't yet find the thread where [USER=13851]@madman[/USER] rounded up the best collection of evidence. But some indirect evidence is contained in [URL='https://www.excelmale.com/forum/threads/confused-about-testosterone-enanthate-half-life.17667/post-137255']this thread[/URL]. In that post Nelson gives the Nieschlag data with a half-life of 4.5 days for testosterone enanthate. Below that [USER=13851]@madman[/USER] [URL='https://www.excelmale.com/forum/threads/confused-about-testosterone-enanthate-half-life.17667/post-137292']includes a study[/URL] showing that cypionate and enanthate have very similar pharmacokinetics. Also check out [URL='https://www.excelmale.com/forum/threads/is-the-feeling-of-well-being-on-trt-dosage-dependent.21477/post-184259']this post[/URL], starting where he says "Cypionate study states the mean/median having a much shorter half-life." Studies showing a longer half-life failed to account for concurrent HPTA activity [INDENT][I][U]It is difficult to calculate the PK parameters of TC using traditional noncompartmental methods[/U], especially when the endogenous testosterone secretion rate is suppressed during the course of TC administration and the testosterone secretion rate is regulated by the LH-testosterone feedback loop system in HPG axis.[/I] [U]Our estimated post hoc median tT half-life was 4.05 days, which is shorter than the mean reported elimination half-life of 6.9 days determined using noncompartmental analysis[/U].11 Such inconsistency is believed to result from failure to consider endogenous testosterone production. [U]When we assume endogenous testosterone secretion is 0 in the PPK analysis, the median estimated half-life increases to 6.87 days[/U].[/INDENT] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How to lower TRT weekly dosage safely?
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