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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
How to lower IGF 1 ?
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<blockquote data-quote="DS3" data-source="post: 171449" data-attributes="member: 18514"><p>Yes... transporting sex steroids in plasma and regulating the distribution between protein-bound sex steroids and free states.</p><p></p><p>So, what are you proposing would be the negative result of low SHBG in male patients on TRT?</p><p></p><p>Would higher free testosterone and testosterone metabolites (E2 and DHT) see higher unbound states in plasma with lower SHBG? Yes. And that is where estrogen control can become difficult, which is the primary issue seen among TRT patients with low SHBG.</p><p></p><p>"Sex hormone binding globulin (SHBG) is a glycoprotein possessing high affinity binding for 17 beta-hydroxysteriod hormones such as testosterone and oestradiol. It is probably synthesized in the liver, plasma concentrations being regulated by, amongst other things, androgen/oestrogen balance, thyroid hormones, insulin and dietary factors, it is involved in transport of sex steroids in plasma and its concentration is a major factor regulating their distribution between the protein-bound and free states."</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/2080856" target="_blank">Sex hormone binding globulin: origin, function and clinical significance. - PubMed - NCBI</a></p></blockquote><p></p>
[QUOTE="DS3, post: 171449, member: 18514"] Yes... transporting sex steroids in plasma and regulating the distribution between protein-bound sex steroids and free states. So, what are you proposing would be the negative result of low SHBG in male patients on TRT? Would higher free testosterone and testosterone metabolites (E2 and DHT) see higher unbound states in plasma with lower SHBG? Yes. And that is where estrogen control can become difficult, which is the primary issue seen among TRT patients with low SHBG. "Sex hormone binding globulin (SHBG) is a glycoprotein possessing high affinity binding for 17 beta-hydroxysteriod hormones such as testosterone and oestradiol. It is probably synthesized in the liver, plasma concentrations being regulated by, amongst other things, androgen/oestrogen balance, thyroid hormones, insulin and dietary factors, it is involved in transport of sex steroids in plasma and its concentration is a major factor regulating their distribution between the protein-bound and free states." [URL='https://www.ncbi.nlm.nih.gov/pubmed/2080856']Sex hormone binding globulin: origin, function and clinical significance. - PubMed - NCBI[/URL] [/QUOTE]
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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
How to lower IGF 1 ?
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