ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
How to Improve Sperm Quality, LH, FSH and Testosterone in Infertile Men
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Sides" data-source="post: 159169" data-attributes="member: 31749"><p>lt84, HMG (mixed FSH and LH) is a great product, and I used it myself in my fertility protocol, as my doctor at first refused to prescribe FSH. But your husband will need to use HCG (which is an LH analogue) along with FSH or HMG.</p><p></p><p>Although there is both LH and FSH in HMG, there is not sufficient LH in HMG to maintain high enough levels of intra-testicular testosterone for optimal spermatogenesis. Plus injected LH has a very short half-life in the body, only a few hours. So that is why we use HCG, along with either HMG or FSH, for regaining fertility. Your husband will need both HCG and either HMG or FSH to get his sperm count up to the highest possible quantity and quality.</p><p></p><p>So have your doctor continue to prescribe HCG, and add either FSH or HMG. But if she prescribes HMG, remember you are only using the HMG for it's FSH, to stimulate the Sertoli cells of the testicles, as there is not enough LH in it to stimulate the Leydig cells of the testicles for maximum benefit.</p><p></p><p>Although I personally used HMG, optimally I would just stick with FSH and HCG just to keep things simple. But my case and others show that either FSH or HMG will work.</p><p></p><p>From the paper Nelson gave you above:</p><p></p><p>"FSH given alone or in combination with testosterone has proven unsuccessful at inducing spermatogenesis or maintaining spermatogenesis in those previously induced with hCG/FSH (hCG 1500 IU and HMG 150 IU both subcutaneous and 3 times per week), confirming the need for maintenance of elevated ITT.46 However, long-term use of hCG alone can induce spermatogenesis in up to 70% of patients, with a greater effect seen in men with initial testis length >4 cm, but further improvement is appreciated with the addition of FSH (HMG) suggesting a timelier recovery with both gonadotropins.47 The success of inducing spermatogenesis with a combination of hCG and FSH is supported by several studies (Table 1).41,42,45,48–53 In these data, most begin by stimulating endogenous testosterone production with trial of hCG alone with doses ranging from 1500 to 5000 IU 2–3 times per week titrated according to serum testosterone levels. Most experts treat with hCG alone for 3–6 months after which a certain number of cases will result in spermatogenesis induction. In those without adequate spermatogenesis induction, treatment proceeds with the addition of FSH with doses ranging from 75 to 400 IU 2–3 times per week titrated according to semen analysis results. Success defined as induction of spermatogenesis with >1–1.5 × 106 ml−1 sperm was reported to occur in 44%–100% of patients treated for 6–144 months.52 Pregnancy rates, when reported, were observed in 40%–75% of patients usually at sperm concentration levels below “normal.”42,51,54 Factors predicting success include larger baseline testis volume, previous natural gonadotropin exposure (normal puberty), and repeated treatment cycles whereas previous exogenous testosterone exposure and cryptorchidism portend a slower response although these findings are variable.42,55 It is important to consider these data are in men with HH due to classic causes and not patients with previous TRT/AAS use in whom better outcomes can theoretically be expected given the likelihood of normal pubertal development and HPG axis function at some point before TRT/AAS exposure."</p></blockquote><p></p>
[QUOTE="Sides, post: 159169, member: 31749"] lt84, HMG (mixed FSH and LH) is a great product, and I used it myself in my fertility protocol, as my doctor at first refused to prescribe FSH. But your husband will need to use HCG (which is an LH analogue) along with FSH or HMG. Although there is both LH and FSH in HMG, there is not sufficient LH in HMG to maintain high enough levels of intra-testicular testosterone for optimal spermatogenesis. Plus injected LH has a very short half-life in the body, only a few hours. So that is why we use HCG, along with either HMG or FSH, for regaining fertility. Your husband will need both HCG and either HMG or FSH to get his sperm count up to the highest possible quantity and quality. So have your doctor continue to prescribe HCG, and add either FSH or HMG. But if she prescribes HMG, remember you are only using the HMG for it's FSH, to stimulate the Sertoli cells of the testicles, as there is not enough LH in it to stimulate the Leydig cells of the testicles for maximum benefit. Although I personally used HMG, optimally I would just stick with FSH and HCG just to keep things simple. But my case and others show that either FSH or HMG will work. From the paper Nelson gave you above: "FSH given alone or in combination with testosterone has proven unsuccessful at inducing spermatogenesis or maintaining spermatogenesis in those previously induced with hCG/FSH (hCG 1500 IU and HMG 150 IU both subcutaneous and 3 times per week), confirming the need for maintenance of elevated ITT.46 However, long-term use of hCG alone can induce spermatogenesis in up to 70% of patients, with a greater effect seen in men with initial testis length >4 cm, but further improvement is appreciated with the addition of FSH (HMG) suggesting a timelier recovery with both gonadotropins.47 The success of inducing spermatogenesis with a combination of hCG and FSH is supported by several studies (Table 1).41,42,45,48–53 In these data, most begin by stimulating endogenous testosterone production with trial of hCG alone with doses ranging from 1500 to 5000 IU 2–3 times per week titrated according to serum testosterone levels. Most experts treat with hCG alone for 3–6 months after which a certain number of cases will result in spermatogenesis induction. In those without adequate spermatogenesis induction, treatment proceeds with the addition of FSH with doses ranging from 75 to 400 IU 2–3 times per week titrated according to semen analysis results. Success defined as induction of spermatogenesis with >1–1.5 × 106 ml−1 sperm was reported to occur in 44%–100% of patients treated for 6–144 months.52 Pregnancy rates, when reported, were observed in 40%–75% of patients usually at sperm concentration levels below “normal.”42,51,54 Factors predicting success include larger baseline testis volume, previous natural gonadotropin exposure (normal puberty), and repeated treatment cycles whereas previous exogenous testosterone exposure and cryptorchidism portend a slower response although these findings are variable.42,55 It is important to consider these data are in men with HH due to classic causes and not patients with previous TRT/AAS use in whom better outcomes can theoretically be expected given the likelihood of normal pubertal development and HPG axis function at some point before TRT/AAS exposure." [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
How to Improve Sperm Quality, LH, FSH and Testosterone in Infertile Men
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top