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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
How to improve penile sensitivity?
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<blockquote data-quote="Nelson Vergel" data-source="post: 121649" data-attributes="member: 3"><p>" Penile erection is a complex process involving psychogenic and hormonal input, and a neurovascular nonadrenergic, noncholinergic mechanism. Nitric oxide (NO) is believed to be the main vasoactive nonadrenergic, noncholinergic neurotransmitter and chemical mediator of penile erection. Released by nerve and endothelial cells in the corpora cavernosa of the penis, NO activates soluble guanylyl cyclase, which increases 3',5'-cyclic guanosine monophosphate (cGMP) levels. Acting as a second messenger molecule, cGMP regulates the activity of calcium channels as well as intracellular contractile proteins that affect the relaxation of corpus cavernosum smooth muscle. Impaired NO bioactivity is a major pathogenic mechanism of erectile dysfunction." <a href="https://www.ncbi.nlm.nih.gov/pubmed/17170606" target="_blank">Reference</a></p><p></p><p>Translation: Nitric oxide is produced by penile inner vascular walls to regulate an enzyme that allows blood in and out of the penis by affecting proteins that are related to contraction and relaxation of blood vessels that make an erection possible.</p><p></p><p>This conversation started with someone posting that they felt a lack of sensitivity when having an induced erection with Trimix. I hypothesized that this may be due to low nitric oxide production. Low NO can cause ED</p><p></p><p></p><p><strong><span style="font-size: 22px">Roles of Nitric Oxide:</span></strong></p><p></p><p><span style="font-size: 18px"><strong>"Vasodilation</strong></span></p><p>Nitric oxide <a href="https://en.wikipedia.org/wiki/Vasodilation" target="_blank">dilates blood vessels</a>, raising blood supply and lowering blood pressure.<a href="https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide#cite_note-vanFaassen-etal-45" target="_blank">[45]</a> Conversely, it helps protect tissues from <a href="https://en.wikipedia.org/wiki/Ischemic_damage" target="_blank">damage due to low blood supply</a>.<a href="https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide#cite_note-vanFaassen-etal-45" target="_blank">[45]</a> Also a <a href="https://en.wikipedia.org/wiki/Neurotransmitter" target="_blank">neurotransmitter</a>, nitric oxide acts in the nitrergic neurons active on <a href="https://en.wikipedia.org/wiki/Smooth_muscle" target="_blank">smooth muscle</a>, abundant in the <a href="https://en.wikipedia.org/wiki/Gastrointestinal_tract" target="_blank">gastrointestinal tract</a> and <a href="https://en.wikipedia.org/wiki/Erectile_tissue" target="_blank">erectile tissue</a>.<a href="https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide#cite_note-Toda-etal-46" target="_blank">[46]</a> <a href="https://en.wikipedia.org/wiki/Sildenafil" target="_blank">sildenafil</a> (Viagra) works to inhibit the enzyme phosphodiesterase <a href="https://en.wikipedia.org/wiki/PDE5" target="_blank">PDE5</a>, which lowers the cGMP concentration by converting it back to <a href="https://en.wikipedia.org/wiki/Guanosine_monophosphate" target="_blank">GMP</a>.</p><p></p><p>Nitric oxide (NO) contributes to vessel homeostasis by inhibiting vascular smooth muscle contraction and growth, platelet aggregation, and leukocyte adhesion to the endothelium. Humans with <a href="https://en.wikipedia.org/wiki/Atherosclerosis" target="_blank">atherosclerosis</a>, <a href="https://en.wikipedia.org/wiki/Diabetes" target="_blank">diabetes</a>, or <a href="https://en.wikipedia.org/wiki/Hypertension" target="_blank">hypertension</a> often show impaired NO pathways.<a href="https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide#cite_note-47" target="_blank">[47]</a></p><p></p><p>Nitric oxide (NO) is a mediator of <a href="https://en.wikipedia.org/wiki/Vasodilation" target="_blank">vasodilation</a> in blood vessels. It is induced by several factors, and once synthesized by eNOS it results in phosphorylation of several proteins that cause smooth muscle relaxation.<a href="https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide#cite_note-ted.com-4" target="_blank">[4]</a> The vasodilatory actions of nitric oxide play a key role in renal control of <a href="https://en.wikipedia.org/wiki/Extracellular_fluid_homeostasis" target="_blank">extracellular fluid homeostasis</a> and is essential for the regulation of blood flow and blood pressure.<a href="https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide#cite_note-48" target="_blank">[48]</a> NO also plays a role in <a href="https://en.wikipedia.org/wiki/Erection" target="_blank">erection</a> of the <a href="https://en.wikipedia.org/wiki/Penis" target="_blank">penis</a> and <a href="https://en.wikipedia.org/wiki/Clitoris" target="_blank">clitoris</a>.<a href="https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide#cite_note-49" target="_blank">[49]</a></p><p></p><p><span style="font-size: 18px"><strong>Cardiac effects</strong></span></p><p>Nitric oxide also acts on <a href="https://en.wikipedia.org/wiki/Cardiac_muscle" target="_blank">cardiac muscle</a> to decrease contractility and <a href="https://en.wikipedia.org/wiki/Heart_rate" target="_blank">heart rate</a>. NO contributes to the regulation of cardiac contractility. Emerging evidence suggests that coronary artery disease (CAD) is related to defects in generation or action of NO.<a href="https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide#cite_note-50" target="_blank">[50]</a> Reduced levels of <a href="https://en.wikipedia.org/wiki/Exhaled_nitric_oxide" target="_blank">exhaled NO</a> have been associated with exposure to traffic-related air pollution.<a href="https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide#cite_note-Jacobs-38" target="_blank">[38</a> " <a href="https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide" target="_blank">Reference</a></p><p></p><p><span style="font-size: 18px"><strong>Click here: </strong></span><a href="https://www.excelmale.com/forum/threads/what-every-man-should-know-about-nitric-oxide.6359/" target="_blank"><span style="font-size: 18px"><strong>What Every Man Should Know About Nitric Oxide</strong></span></a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 121649, member: 3"] " Penile erection is a complex process involving psychogenic and hormonal input, and a neurovascular nonadrenergic, noncholinergic mechanism. Nitric oxide (NO) is believed to be the main vasoactive nonadrenergic, noncholinergic neurotransmitter and chemical mediator of penile erection. Released by nerve and endothelial cells in the corpora cavernosa of the penis, NO activates soluble guanylyl cyclase, which increases 3',5'-cyclic guanosine monophosphate (cGMP) levels. Acting as a second messenger molecule, cGMP regulates the activity of calcium channels as well as intracellular contractile proteins that affect the relaxation of corpus cavernosum smooth muscle. Impaired NO bioactivity is a major pathogenic mechanism of erectile dysfunction." [URL='https://www.ncbi.nlm.nih.gov/pubmed/17170606']Reference[/URL] Translation: Nitric oxide is produced by penile inner vascular walls to regulate an enzyme that allows blood in and out of the penis by affecting proteins that are related to contraction and relaxation of blood vessels that make an erection possible. This conversation started with someone posting that they felt a lack of sensitivity when having an induced erection with Trimix. I hypothesized that this may be due to low nitric oxide production. Low NO can cause ED [B][SIZE=22px]Roles of Nitric Oxide:[/SIZE][/B] [SIZE=18px][B]"Vasodilation[/B][/SIZE] Nitric oxide [URL='https://en.wikipedia.org/wiki/Vasodilation']dilates blood vessels[/URL], raising blood supply and lowering blood pressure.[URL='https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide#cite_note-vanFaassen-etal-45'][45][/URL] Conversely, it helps protect tissues from [URL='https://en.wikipedia.org/wiki/Ischemic_damage']damage due to low blood supply[/URL].[URL='https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide#cite_note-vanFaassen-etal-45'][45][/URL] Also a [URL='https://en.wikipedia.org/wiki/Neurotransmitter']neurotransmitter[/URL], nitric oxide acts in the nitrergic neurons active on [URL='https://en.wikipedia.org/wiki/Smooth_muscle']smooth muscle[/URL], abundant in the [URL='https://en.wikipedia.org/wiki/Gastrointestinal_tract']gastrointestinal tract[/URL] and [URL='https://en.wikipedia.org/wiki/Erectile_tissue']erectile tissue[/URL].[URL='https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide#cite_note-Toda-etal-46'][46][/URL] [URL='https://en.wikipedia.org/wiki/Sildenafil']sildenafil[/URL] (Viagra) works to inhibit the enzyme phosphodiesterase [URL='https://en.wikipedia.org/wiki/PDE5']PDE5[/URL], which lowers the cGMP concentration by converting it back to [URL='https://en.wikipedia.org/wiki/Guanosine_monophosphate']GMP[/URL]. Nitric oxide (NO) contributes to vessel homeostasis by inhibiting vascular smooth muscle contraction and growth, platelet aggregation, and leukocyte adhesion to the endothelium. Humans with [URL='https://en.wikipedia.org/wiki/Atherosclerosis']atherosclerosis[/URL], [URL='https://en.wikipedia.org/wiki/Diabetes']diabetes[/URL], or [URL='https://en.wikipedia.org/wiki/Hypertension']hypertension[/URL] often show impaired NO pathways.[URL='https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide#cite_note-47'][47][/URL] Nitric oxide (NO) is a mediator of [URL='https://en.wikipedia.org/wiki/Vasodilation']vasodilation[/URL] in blood vessels. It is induced by several factors, and once synthesized by eNOS it results in phosphorylation of several proteins that cause smooth muscle relaxation.[URL='https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide#cite_note-ted.com-4'][4][/URL] The vasodilatory actions of nitric oxide play a key role in renal control of [URL='https://en.wikipedia.org/wiki/Extracellular_fluid_homeostasis']extracellular fluid homeostasis[/URL] and is essential for the regulation of blood flow and blood pressure.[URL='https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide#cite_note-48'][48][/URL] NO also plays a role in [URL='https://en.wikipedia.org/wiki/Erection']erection[/URL] of the [URL='https://en.wikipedia.org/wiki/Penis']penis[/URL] and [URL='https://en.wikipedia.org/wiki/Clitoris']clitoris[/URL].[URL='https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide#cite_note-49'][49][/URL] [SIZE=18px][B]Cardiac effects[/B][/SIZE] Nitric oxide also acts on [URL='https://en.wikipedia.org/wiki/Cardiac_muscle']cardiac muscle[/URL] to decrease contractility and [URL='https://en.wikipedia.org/wiki/Heart_rate']heart rate[/URL]. NO contributes to the regulation of cardiac contractility. Emerging evidence suggests that coronary artery disease (CAD) is related to defects in generation or action of NO.[URL='https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide#cite_note-50'][50][/URL] Reduced levels of [URL='https://en.wikipedia.org/wiki/Exhaled_nitric_oxide']exhaled NO[/URL] have been associated with exposure to traffic-related air pollution.[URL='https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide#cite_note-Jacobs-38'][38[/URL] " [URL='https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide']Reference[/URL] [SIZE=18px][B]Click here: [/B][/SIZE][URL='https://www.excelmale.com/forum/threads/what-every-man-should-know-about-nitric-oxide.6359/'][SIZE=18px][B]What Every Man Should Know About Nitric Oxide[/B][/SIZE][/URL] [/QUOTE]
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