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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
How quickly does Aromatization occur?
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<blockquote data-quote="Cataceous" data-source="post: 221697" data-attributes="member: 38109"><p>Both testosterone and estradiol rise quickly within a day of an injection; estradiol follows testosterone, as testosterone is its primary ingredient. The conversion rate also depends on the current amount of aromatase. A separate issue is the extent to which TRT and/or enclomiphene can change the amount of aromatase over time. And you bring up another question: Can effects on aromatase persist after treatment is ended? The regulation of aromatase is complex and location-dependent. Wikipedia notes "Aromatase is localized in the endoplasmic reticulum where it is <strong>regulated by tissue-specific promoters</strong> that are in turn <strong>controlled by hormones, cytokines, and other factors</strong>." With so many factors going into an overall observed rate of aromatization, it's little surprise that conflicting anecdotes are common.</p><p></p><p>Keep in mind that at a fixed testosterone dose rate, changes in SHBG do not have much effect on the levels of the free hormones. Free hormone levels are driven directly by the dose or production rates. In contrast, total hormone levels vary as a function of their free hormone levels, along with other variables, such as the levels of SHBG and albumin.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 221697, member: 38109"] Both testosterone and estradiol rise quickly within a day of an injection; estradiol follows testosterone, as testosterone is its primary ingredient. The conversion rate also depends on the current amount of aromatase. A separate issue is the extent to which TRT and/or enclomiphene can change the amount of aromatase over time. And you bring up another question: Can effects on aromatase persist after treatment is ended? The regulation of aromatase is complex and location-dependent. Wikipedia notes "Aromatase is localized in the endoplasmic reticulum where it is [B]regulated by tissue-specific promoters[/B] that are in turn [B]controlled by hormones, cytokines, and other factors[/B]." With so many factors going into an overall observed rate of aromatization, it's little surprise that conflicting anecdotes are common. Keep in mind that at a fixed testosterone dose rate, changes in SHBG do not have much effect on the levels of the free hormones. Free hormone levels are driven directly by the dose or production rates. In contrast, total hormone levels vary as a function of their free hormone levels, along with other variables, such as the levels of SHBG and albumin. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
How quickly does Aromatization occur?
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