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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How often to test SHBG?
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<blockquote data-quote="Cataceous" data-source="post: 153188" data-attributes="member: 38109"><p>I stopped hCG at the behest of a clinic giving me some joint injections, because they claim to have data showing that hCG "lowers total nucleated cell counts." I'd been on it for four years. The estradiol crash happened after stopping hCG, which is why I speculated that hCG use had suppressed extra-testicular estradiol production. I expected a reduction in estradiol due to loss of intra-testicular production, but that's only 15-25% of the total according to Wiki's references. The rest does come from the peripheral tissues.</p><p></p><p></p><p>I don't know enough about what stimulates or suppresses aromatase to state a plausible mechanism.</p><p></p><p></p><p>I did try enclomiphene for a period and it was insufficient to overcome the suppression of TRT.</p><p></p><p></p><p>It's nonlinear, but in the opposite direction. The aromatase enzymes start to saturate with additional testosterone, so the rate of increase in estradiol decreases with increasing testosterone.</p><p></p><p></p><p>Hard to say, but this could be showing a recovery in aromatase as times goes on. Or it could just be random fluctuations.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 153188, member: 38109"] I stopped hCG at the behest of a clinic giving me some joint injections, because they claim to have data showing that hCG "lowers total nucleated cell counts." I'd been on it for four years. The estradiol crash happened after stopping hCG, which is why I speculated that hCG use had suppressed extra-testicular estradiol production. I expected a reduction in estradiol due to loss of intra-testicular production, but that's only 15-25% of the total according to Wiki's references. The rest does come from the peripheral tissues. I don't know enough about what stimulates or suppresses aromatase to state a plausible mechanism. I did try enclomiphene for a period and it was insufficient to overcome the suppression of TRT. It's nonlinear, but in the opposite direction. The aromatase enzymes start to saturate with additional testosterone, so the rate of increase in estradiol decreases with increasing testosterone. Hard to say, but this could be showing a recovery in aromatase as times goes on. Or it could just be random fluctuations. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How often to test SHBG?
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