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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How often to test SHBG?
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<blockquote data-quote="DragonBits" data-source="post: 153160" data-attributes="member: 18023"><p>Why did you stop HCG, how long were you taking it, meaning what is "chronic", and why did do you think HCG might have caused this?</p><p></p><p>If it did cause it, what is the mechanism that might have caused this, some kind of over stimulation, what is your theory about why HCG might have caused this?</p><p></p><p>I know aromatase activity is what causes the conversion of T > E2, but aromatase is present in many places like the bone and brain but there it is Paracrine action: the hormone acts locally. I am not sure about where the aromatase enzyme is that is responsible for serum levels of E2?</p><p></p><p>To further complicate the issue, I imagine that serum levels of E2 are not always reflective of bone, brain levels of E2 and does serum levels of E2 affect bone / brain levels?</p><p></p><p>I have never had a whole lot of serum E2, when totally off external hormones my E2 was <5 with ~350 total T. Only when my total T got up to 1300 was my E2 over range at 56 pg/ml. But I didn't have any seriously noticeable effects of low E2 even though it must have been low for 10 years before TRT, my joints seemed to be more sensitive to stress, however that is somewhat subjective and depends on how much stress I have applied. </p><p></p><p><strong>Clomid</strong> really caused a big increase in E2, you might try that. On clomid (no TRT) I had an E2 of 27 with a total T of 478. I was taking 50 mg every other day. Clomid blocks the hormone estrogen from interacting with the pituitary gland, <strong>however</strong>, I am not sure Clomid would be effective while on TRT as CLomid increases LH/FSH, which should be near zero on TRT. </p><p></p><p>One assumption I had, E2 conversions isn't linear, meaning double your total T and at some point you get more than double E2. Does anyone think that is true?</p><p></p><p>Here is another blood test taken in 6-2019, that is a year after stopping HCG while still on TRT, but I have no idea what my SHBG was.</p><p></p><p>Testosterone,Free and Total</p><p>Testosterone, Serum 612 ng/dL 264 - 916 01</p><p>Free Testosterone(Direct) 10.0 pg/mL 6.6 - 18.1 02</p><p></p><p>Estradiol, Sensitive 17.3 pg/mL 8.0 - 35.0 02</p><p>Methodology: Liquid chromatography tandem mass spectrometry(LC/MS/MS)</p></blockquote><p></p>
[QUOTE="DragonBits, post: 153160, member: 18023"] Why did you stop HCG, how long were you taking it, meaning what is "chronic", and why did do you think HCG might have caused this? If it did cause it, what is the mechanism that might have caused this, some kind of over stimulation, what is your theory about why HCG might have caused this? I know aromatase activity is what causes the conversion of T > E2, but aromatase is present in many places like the bone and brain but there it is Paracrine action: the hormone acts locally. I am not sure about where the aromatase enzyme is that is responsible for serum levels of E2? To further complicate the issue, I imagine that serum levels of E2 are not always reflective of bone, brain levels of E2 and does serum levels of E2 affect bone / brain levels? I have never had a whole lot of serum E2, when totally off external hormones my E2 was <5 with ~350 total T. Only when my total T got up to 1300 was my E2 over range at 56 pg/ml. But I didn't have any seriously noticeable effects of low E2 even though it must have been low for 10 years before TRT, my joints seemed to be more sensitive to stress, however that is somewhat subjective and depends on how much stress I have applied. [B]Clomid[/B] really caused a big increase in E2, you might try that. On clomid (no TRT) I had an E2 of 27 with a total T of 478. I was taking 50 mg every other day. Clomid blocks the hormone estrogen from interacting with the pituitary gland, [B]however[/B], I am not sure Clomid would be effective while on TRT as CLomid increases LH/FSH, which should be near zero on TRT. One assumption I had, E2 conversions isn't linear, meaning double your total T and at some point you get more than double E2. Does anyone think that is true? Here is another blood test taken in 6-2019, that is a year after stopping HCG while still on TRT, but I have no idea what my SHBG was. Testosterone,Free and Total Testosterone, Serum 612 ng/dL 264 - 916 01 Free Testosterone(Direct) 10.0 pg/mL 6.6 - 18.1 02 Estradiol, Sensitive 17.3 pg/mL 8.0 - 35.0 02 Methodology: Liquid chromatography tandem mass spectrometry(LC/MS/MS) [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How often to test SHBG?
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