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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How often to test SHBG?
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<blockquote data-quote="Cataceous" data-source="post: 153063" data-attributes="member: 38109"><p>Six months is too much time elapsed to assume other variables have not changed significantly. The T/E2 ratios are inconsistent, due either to measurement variations/errors or changes in aromatase. [Edit: missed the part about hCG; that explains the E2]</p><p></p><p></p><p>The idea is based mainly on theory, but it also seems to be supported by my recent lab results.</p><p></p><p>The hypothesis is pretty easy to explain: On TRT you are absorbing testosterone at a rate that is independent of existing hormonal parameters. For simplicity, assume it's constant. Now suppose SHBG suddenly drops. What happens after things have settled down—within a few hours? Because it's a new steady state, the clearance rate of testosterone must still be equal to the absorption rate—otherwise testosterone would be increasing or decreasing. The clearance rate is proportional to free testosterone, therefore free testosterone must return to it's previous value at steady state. With lower SHBG, achieving the same free testosterone implies lower total testosterone. The predicted changes can be determined with a free T calculator.</p><p></p><p>Estradiol will behave the same way, with free estradiol returning to its starting value while total estradiol adjusts to account for the new SHBG.</p><p></p><p>This assumes other parameters related to MCR(T) remain constant, which of course may not hold over longer periods of time.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 153063, member: 38109"] Six months is too much time elapsed to assume other variables have not changed significantly. The T/E2 ratios are inconsistent, due either to measurement variations/errors or changes in aromatase. [Edit: missed the part about hCG; that explains the E2] The idea is based mainly on theory, but it also seems to be supported by my recent lab results. The hypothesis is pretty easy to explain: On TRT you are absorbing testosterone at a rate that is independent of existing hormonal parameters. For simplicity, assume it's constant. Now suppose SHBG suddenly drops. What happens after things have settled down—within a few hours? Because it's a new steady state, the clearance rate of testosterone must still be equal to the absorption rate—otherwise testosterone would be increasing or decreasing. The clearance rate is proportional to free testosterone, therefore free testosterone must return to it's previous value at steady state. With lower SHBG, achieving the same free testosterone implies lower total testosterone. The predicted changes can be determined with a free T calculator. Estradiol will behave the same way, with free estradiol returning to its starting value while total estradiol adjusts to account for the new SHBG. This assumes other parameters related to MCR(T) remain constant, which of course may not hold over longer periods of time. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How often to test SHBG?
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