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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How much testosterone is converted to estradiol?
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<blockquote data-quote="Dr Justin Saya MD" data-source="post: 53789" data-attributes="member: 12687"><p>I hope not too many have a consistent T level of 1500ng/dL (not my patients anyway...unless very high SHBG and consequently need higher total T to increase free T). </p><p></p><p>I've been trying to glean some useful clinical info from free T to E2 relationships. </p><p></p><p>Thus, lets say for a patient with a more appropriate T level of 1000ng/dL. </p><p></p><p>The 0.3% (0.003) conversion factor would equate to an estradiol of 3ng/dL = 30pg/mL. This also lies within the classic range we see for FREE T levels with total T levels around 1000ng/dL (typically free T will be in the neighborhood of 25-35pg/mL...sometimes significantly higher or lower depending on concurrent SHBG levels). </p><p></p><p>Specifically, I'm looking into patterns to see if anything "jumps out" with regards to symptoms, quality of life, libido, etc for the different scenarios: free T < estradiol , free T = estradiol, free T > estradiol. I'm starting to lean towards patients generally feeling "better" when: free T equals or greater than estradiol, as opposed to less than estradiol. However, there are so many moving parts/variables that it is a complex analysis.</p><p></p><p>So for the hypothetical patient with total T 1000ng/dL , estradiol 30pg/ml, would *want* free T equal to or greater than 30pg/mL. Again, this is preliminary and a tough analysis as everyone is different and cases of very high or very low SHBG can really skew things and alter even the most reliable patterns. I'm going to keep watching these parameters for clues to better help my patients.</p></blockquote><p></p>
[QUOTE="Dr Justin Saya MD, post: 53789, member: 12687"] I hope not too many have a consistent T level of 1500ng/dL (not my patients anyway...unless very high SHBG and consequently need higher total T to increase free T). I've been trying to glean some useful clinical info from free T to E2 relationships. Thus, lets say for a patient with a more appropriate T level of 1000ng/dL. The 0.3% (0.003) conversion factor would equate to an estradiol of 3ng/dL = 30pg/mL. This also lies within the classic range we see for FREE T levels with total T levels around 1000ng/dL (typically free T will be in the neighborhood of 25-35pg/mL...sometimes significantly higher or lower depending on concurrent SHBG levels). Specifically, I'm looking into patterns to see if anything "jumps out" with regards to symptoms, quality of life, libido, etc for the different scenarios: free T < estradiol , free T = estradiol, free T > estradiol. I'm starting to lean towards patients generally feeling "better" when: free T equals or greater than estradiol, as opposed to less than estradiol. However, there are so many moving parts/variables that it is a complex analysis. So for the hypothetical patient with total T 1000ng/dL , estradiol 30pg/ml, would *want* free T equal to or greater than 30pg/mL. Again, this is preliminary and a tough analysis as everyone is different and cases of very high or very low SHBG can really skew things and alter even the most reliable patterns. I'm going to keep watching these parameters for clues to better help my patients. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How much testosterone is converted to estradiol?
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