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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How much testosterone is converted to estradiol?
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<blockquote data-quote="tareload" data-source="post: 189054"><p>Very nice. Nelson's factor of 10 solution sorta works with the Tru-T numbers (slope would be closer to 1.5 ish if you used the calc Vermeulen numbers (for someone with reasonable SHBG). So direct RIA off by a factor of 14 (in comparison with Tru-T) or ~5-6 (in comparison with Calc Vermeulen free T).</p><p></p><p>Thanks for putting that graphic together.</p><p></p><p>This plot looks similar to your plot:</p><p></p><p>[ATTACH=full]11147[/ATTACH]</p><p>[ATTACH=full]11149[/ATTACH]</p><p></p><p></p><p>[URL unfurl="true"]https://www.tandfonline.com/doi/abs/10.3109/13685538.2013.835800?journalCode=itam20[/URL]</p><p></p><p>In recent years, the RIA method has been criticized by</p><p>some experts as inaccurate due to substantial numerical</p><p>discrepancies between RIA and EqD results, and too heavily</p><p>influenced by either TT [7] or by SHBG [8]. The numerical</p><p>differences lead to confusion in interpreting clinical results</p><p>and can complicate efforts to establish biochemical standards</p><p>for the diagnosis of TD. Based on these issues, some experts</p><p>advocate that the RIA method should not be used in clinical</p><p>care and that conclusions of previous research studies</p><p>utilizing the RIA method may not be valid [9]. Nonetheless,</p><p>RIA remains in widespread use and some authors have argued</p><p>it provides clinically meaningful information in men when</p><p>interpreted using an assay-specific reference range [10].</p><p>Currently, there is a paucity of data directly comparing the</p><p>two methods against the gold standard in a clinical population</p><p>of men. Our goal in this study is to examine the relationships</p><p>between RIA, cFT, EqD, and TT in a population of men</p><p>presenting to an outpatient andrology clinic.</p><p></p><p>[ATTACH=full]11148[/ATTACH]</p><p></p><p></p><p>[ATTACH=full]11150[/ATTACH]</p></blockquote><p></p>
[QUOTE="tareload, post: 189054"] Very nice. Nelson's factor of 10 solution sorta works with the Tru-T numbers (slope would be closer to 1.5 ish if you used the calc Vermeulen numbers (for someone with reasonable SHBG). So direct RIA off by a factor of 14 (in comparison with Tru-T) or ~5-6 (in comparison with Calc Vermeulen free T). Thanks for putting that graphic together. This plot looks similar to your plot: [ATTACH type="full" alt="1602705734454.png"]11147[/ATTACH] [ATTACH type="full" alt="1602706050146.png"]11149[/ATTACH] [URL unfurl="true"]https://www.tandfonline.com/doi/abs/10.3109/13685538.2013.835800?journalCode=itam20[/URL] In recent years, the RIA method has been criticized by some experts as inaccurate due to substantial numerical discrepancies between RIA and EqD results, and too heavily influenced by either TT [7] or by SHBG [8]. The numerical differences lead to confusion in interpreting clinical results and can complicate efforts to establish biochemical standards for the diagnosis of TD. Based on these issues, some experts advocate that the RIA method should not be used in clinical care and that conclusions of previous research studies utilizing the RIA method may not be valid [9]. Nonetheless, RIA remains in widespread use and some authors have argued it provides clinically meaningful information in men when interpreted using an assay-specific reference range [10]. Currently, there is a paucity of data directly comparing the two methods against the gold standard in a clinical population of men. Our goal in this study is to examine the relationships between RIA, cFT, EqD, and TT in a population of men presenting to an outpatient andrology clinic. [ATTACH type="full" alt="1602705903515.png"]11148[/ATTACH] [ATTACH type="full"]11150[/ATTACH] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How much testosterone is converted to estradiol?
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