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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How much testosterone is converted to estradiol?
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<blockquote data-quote="Cataceous" data-source="post: 188803" data-attributes="member: 38109"><p>If only things were so simple. [USER=13851]@madman[/USER] has extensively documented why these immunoassay-based tests should not be used. A sample:</p><p></p><p><em>The older, direct analogue RIA methods have been discredited and are no longer recommended for use [6–8].</em>[<a href="https://pubmed.ncbi.nlm.nih.gov/30970279/" target="_blank">R</a>]</p><p></p><p><em>An analog-based free testosterone immunoassay reported free testosterone test results that were related to total testosterone concentrations under varied experimental conditions. This alleged free testosterone assay did not detect serum free testosterone (the test results it reported were nonspecific) and should not be used for this purpose.</em>[<a href="https://academic.oup.com/clinchem/article/54/3/512/5628433" target="_blank">R</a>]</p><p></p><p>... <em>this class of assay has been criticized as having poor accuracy, sensitivity, and between-assay comparability and being influenced by the dilution of serum (2)(3)(4)(5)(6). <strong>It is of note that the reference interval for free T by analog-based assay is much lower (concentrations about one-fifth as high) than that for the equilibrium dialysis assay </strong>(2). <strong>This calibration difference between assays is a major problem</strong>.</em>[<a href="https://academic.oup.com/clinchem/article/54/3/458/5628466" target="_blank">R</a>]</p><p></p><p>The problems with LabCorp's direct free T test are even borne out in my results. Using results from tests on the same days, see how the Tru-T free testosterone calculation compares to LabCorp's direct test results. Linearity is the expected result:</p><p>[ATTACH=full]11096[/ATTACH][ATTACH=full]11097[/ATTACH]</p></blockquote><p></p>
[QUOTE="Cataceous, post: 188803, member: 38109"] If only things were so simple. [USER=13851]@madman[/USER] has extensively documented why these immunoassay-based tests should not be used. A sample: [I]The older, direct analogue RIA methods have been discredited and are no longer recommended for use [6–8].[/I][[URL='https://pubmed.ncbi.nlm.nih.gov/30970279/']R[/URL]] [I]An analog-based free testosterone immunoassay reported free testosterone test results that were related to total testosterone concentrations under varied experimental conditions. This alleged free testosterone assay did not detect serum free testosterone (the test results it reported were nonspecific) and should not be used for this purpose.[/I][[URL='https://academic.oup.com/clinchem/article/54/3/512/5628433']R[/URL]] ... [I]this class of assay has been criticized as having poor accuracy, sensitivity, and between-assay comparability and being influenced by the dilution of serum (2)(3)(4)(5)(6). [B]It is of note that the reference interval for free T by analog-based assay is much lower (concentrations about one-fifth as high) than that for the equilibrium dialysis assay [/B](2). [B]This calibration difference between assays is a major problem[/B].[/I][[URL='https://academic.oup.com/clinchem/article/54/3/458/5628466']R[/URL]] The problems with LabCorp's direct free T test are even borne out in my results. Using results from tests on the same days, see how the Tru-T free testosterone calculation compares to LabCorp's direct test results. Linearity is the expected result: [ATTACH type="full" width="300px"]11096[/ATTACH][ATTACH type="full" width="300px"]11097[/ATTACH] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How much testosterone is converted to estradiol?
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