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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How much testosterone is converted to estradiol?
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<blockquote data-quote="Cataceous" data-source="post: 188343" data-attributes="member: 38109"><p>Rather than saying that LabCorp's units for the direct free T test are wrong, it might be better to say that they are measuring some other parameter that is somewhat correlated with free testosterone. The correlation of direct free T with actual free T is only so-so, and you should not simply multiply by 10 to make the comparison. Equilibrium dialysis tests are said to be the gold standard for measuring free testosterone, but even with these I don't think there is yet harmonization allowing direct comparisons between different labs. The Tru-T free T calculation is supposed to correlate well with equilibrium dialysis. And the parameters it uses—total T, SHBG and albumin—suffer from less variation between different labs. Therefore it is a good candidate for generating a more universally comparable value, which may also be used in these ratios.</p><p></p><p>It seems likely that among the various possible ratios, the relative amounts of the free hormones should have the most importance. That is, how does free estradiol compare to free testosterone? This comparison accounts for differing SHBG levels. It's already known that for a fixed free estradiol level—which is the primary HPTA regulator—lower SHBG means that free testosterone is relatively lower than free estradiol. This is thought to be one of the reasons why men with low SHBG face greater challenges.</p><p></p><p>[USER=16947]@S1W[/USER]: It does appear that in 2016 Dr. Saya was relying on the LabCorp direct free T test with normal range 7.2-24 pg/mL. But to require estradiol to be lower than these numbers seems to be pushing it pretty low. The conversion factor from testosterone to estradiol that he's citing, 0.3%, seems at the very low end of normal to me. I would have said 0.4-0.5% is more typical.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 188343, member: 38109"] Rather than saying that LabCorp's units for the direct free T test are wrong, it might be better to say that they are measuring some other parameter that is somewhat correlated with free testosterone. The correlation of direct free T with actual free T is only so-so, and you should not simply multiply by 10 to make the comparison. Equilibrium dialysis tests are said to be the gold standard for measuring free testosterone, but even with these I don't think there is yet harmonization allowing direct comparisons between different labs. The Tru-T free T calculation is supposed to correlate well with equilibrium dialysis. And the parameters it uses—total T, SHBG and albumin—suffer from less variation between different labs. Therefore it is a good candidate for generating a more universally comparable value, which may also be used in these ratios. It seems likely that among the various possible ratios, the relative amounts of the free hormones should have the most importance. That is, how does free estradiol compare to free testosterone? This comparison accounts for differing SHBG levels. It's already known that for a fixed free estradiol level—which is the primary HPTA regulator—lower SHBG means that free testosterone is relatively lower than free estradiol. This is thought to be one of the reasons why men with low SHBG face greater challenges. [USER=16947]@S1W[/USER]: It does appear that in 2016 Dr. Saya was relying on the LabCorp direct free T test with normal range 7.2-24 pg/mL. But to require estradiol to be lower than these numbers seems to be pushing it pretty low. The conversion factor from testosterone to estradiol that he's citing, 0.3%, seems at the very low end of normal to me. I would have said 0.4-0.5% is more typical. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How much testosterone is converted to estradiol?
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