ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
General Health & Fitness
Nutrition and Supplements
How Much Fish Oil is Enough?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="IntelligentLabs" data-source="post: 46333" data-attributes="member: 13584"><p>Hey Fireproof,</p><p></p><p>Thanks for the reference, it's an excellent article.</p><p></p><p>So they look at 3g of omega 3 when there is a mixed EPA/DHA supplement, with 1.2g DHA and 1.8g EPA at reaching blood plasma 'saturation'. However, plasma levels will still keep increasing at higher doses, just the increases are incremental at that point (a point of diminishing returns).</p><p></p><p>It is worth noting that they are using an ethyl ester omega 3 which is less well absorbed, so you would see this 'saturation' level at a lower dosage with a triglyceride fish oil.</p><p></p><p>[ATTACH]2282[/ATTACH]</p><p>Dose-response analysis of the effect of human supplementation with docosahexaenoic acid (DHA) plus eicosapentaenoic acid (EPA) for 12 wk on EPA (&#9830<img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite2" alt=";)" title="Wink ;)" loading="lazy" data-shortname=";)" />, DHA (&#9642<img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite2" alt=";)" title="Wink ;)" loading="lazy" data-shortname=";)" />, and arachidonic acid (&#9652<img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite2" alt=";)" title="Wink ;)" loading="lazy" data-shortname=";)" />. Adapted from reference<a href="http://ajcn.nutrition.org/content/83/6/S1467.long#ref-74" target="_blank">74</a> with permission from the American Society for Clinical Nutrition.</p><p></p><p>There's also the question of whether different doses affect the different levels of DHA in body tissues, although this much more difficult to measure due to needing tissue biopsy, however studies have noted a decent correlation between plasma DHA and cerebral cortex DHA, as well as plasma DHA and maternal breast milk DHA.</p><p></p><p>The following graph shows tissue levels of DHA, EPA, ALA and ARA.</p><p></p><p>[ATTACH]2283[/ATTACH]</p><p></p><p></p><p>Going forward what I hope to see is more &#8216;personalised' dosages coming into play looking at Blood plasma % levels of omega 3 (the Omega 3 Index) and the EPA/AA ratio, as well as tissue levels of DHA.</p><p></p><p></p><p>In terms of heart protection an omega 3 index of >8% sees a dramatic drop in cardiac events (i.e heart attacks, heart disease etc) and that has been suggested to be achieved with 1.8 to 1.9 grams of omega 3 a day</p><p>in this study, although the dose that will reach this is dependant on age, bodyweight, and physical activity.</p><p></p><p>[ATTACH]2284[/ATTACH]</p><p></p><p><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886744/" target="_blank">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886744/</a></p><p></p><p></p><p></p><p>An EPA/AA ratio of >0.75 has also been associated with a significant drop in cardiac events, and these guys found a dose of 4grams of omega 3 a day would on average lead to a 0.9 ratio. Although this again was with an ethyl ester omega 3, so it should be able to be achieved with a significantly lower triglyceride omega 3</p><p></p><p></p><p><a href="http://ajcn.nutrition.org/content/77/1/37.long" target="_blank">http://ajcn.nutrition.org/content/77/1/37.long</a></p></blockquote><p></p>
[QUOTE="IntelligentLabs, post: 46333, member: 13584"] Hey Fireproof, Thanks for the reference, it's an excellent article. So they look at 3g of omega 3 when there is a mixed EPA/DHA supplement, with 1.2g DHA and 1.8g EPA at reaching blood plasma 'saturation'. However, plasma levels will still keep increasing at higher doses, just the increases are incremental at that point (a point of diminishing returns). It is worth noting that they are using an ethyl ester omega 3 which is less well absorbed, so you would see this 'saturation' level at a lower dosage with a triglyceride fish oil. [ATTACH=CONFIG]2282[/ATTACH] Dose-response analysis of the effect of human supplementation with docosahexaenoic acid (DHA) plus eicosapentaenoic acid (EPA) for 12 wk on EPA (♦), DHA (▪), and arachidonic acid (▴). Adapted from reference[URL="http://ajcn.nutrition.org/content/83/6/S1467.long#ref-74"]74[/URL] with permission from the American Society for Clinical Nutrition. There's also the question of whether different doses affect the different levels of DHA in body tissues, although this much more difficult to measure due to needing tissue biopsy, however studies have noted a decent correlation between plasma DHA and cerebral cortex DHA, as well as plasma DHA and maternal breast milk DHA. The following graph shows tissue levels of DHA, EPA, ALA and ARA. [ATTACH=CONFIG]2283[/ATTACH] Going forward what I hope to see is more ‘personalised' dosages coming into play looking at Blood plasma % levels of omega 3 (the Omega 3 Index) and the EPA/AA ratio, as well as tissue levels of DHA. In terms of heart protection an omega 3 index of >8% sees a dramatic drop in cardiac events (i.e heart attacks, heart disease etc) and that has been suggested to be achieved with 1.8 to 1.9 grams of omega 3 a day in this study, although the dose that will reach this is dependant on age, bodyweight, and physical activity. [ATTACH=CONFIG]2284[/ATTACH] [URL]http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886744/[/URL] An EPA/AA ratio of >0.75 has also been associated with a significant drop in cardiac events, and these guys found a dose of 4grams of omega 3 a day would on average lead to a 0.9 ratio. Although this again was with an ethyl ester omega 3, so it should be able to be achieved with a significantly lower triglyceride omega 3 [URL]http://ajcn.nutrition.org/content/77/1/37.long[/URL] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
General Health & Fitness
Nutrition and Supplements
How Much Fish Oil is Enough?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top