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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How much does Estradiol generally vary between injections?
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<blockquote data-quote="Cataceous" data-source="post: 144053" data-attributes="member: 38109"><p>Setting aside the pessimism of my colleagues, I'll try to at least put limits on the number: Assume the following:</p><ul> <li data-xf-list-type="ul">E3.5D injections</li> <li data-xf-list-type="ul">Trough estradiol of 20 pg/mL</li> <li data-xf-list-type="ul">Serum testosterone peaks reached one day after injections</li> <li data-xf-list-type="ul">Exponential decay from peaks with 6-day half life</li> </ul><p>Under these conditions serum testosterone is expected to drop 25% from peaks to troughs. Neglecting the time lag in estradiol you would expect to see estradiol drop in proportion to testosterone. This sets an upper limit for peak estradiol at about 27 pg/mL. Derating this for dynamic estradiol gets trickier. One study on normal males showed relative diurnal estradiol variation to be as little as 40% of testosterone variation. This figure can be used to derive a lower limit on peak estradiol of 22 pg/mL. So the answer in this example is that peak estradiol is expected to be around 22-27 pg/mL.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 144053, member: 38109"] Setting aside the pessimism of my colleagues, I'll try to at least put limits on the number: Assume the following: [LIST] [*]E3.5D injections [*]Trough estradiol of 20 pg/mL [*]Serum testosterone peaks reached one day after injections [*]Exponential decay from peaks with 6-day half life [/LIST] Under these conditions serum testosterone is expected to drop 25% from peaks to troughs. Neglecting the time lag in estradiol you would expect to see estradiol drop in proportion to testosterone. This sets an upper limit for peak estradiol at about 27 pg/mL. Derating this for dynamic estradiol gets trickier. One study on normal males showed relative diurnal estradiol variation to be as little as 40% of testosterone variation. This figure can be used to derive a lower limit on peak estradiol of 22 pg/mL. So the answer in this example is that peak estradiol is expected to be around 22-27 pg/mL. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How much does Estradiol generally vary between injections?
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