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I've done it both ways with an without adex. I have been on and off TRT for over 2 years. I don't feel any different if my E2 is 17 or if it is 40. I do recall Dr Rand saying that elevated estrogens may lead to prostate cancer long term so it is best to control this level and he advocated (at least at one time) keeping E2 in that range although many of his strength athletes felt better at 35 E2. I subscribe to this theory wrong or right. It might not matter 17 or 40, but I don't want it to be 80. I'm not a heavy aromatizer bc my T:E2 ration with no AI tends to be about 30.

[QUOTE="Stoak, post: 232546, member: 40735"] I've done it both ways with an without adex. I have been on and off TRT for over 2 years. I don't feel any different if my E2 is 17 or if it is 40. I do recall Dr Rand saying that elevated estrogens may lead to prostate cancer long term so it is best to control this level and he advocated (at least at one time) keeping E2 in that range although many of his strength athletes felt better at 35 E2. I subscribe to this theory wrong or right. It might not matter 17 or 40, but I don't want it to be 80. I'm not a heavy aromatizer bc my T:E2 ration with no AI tends to be about 30. [/QUOTE]

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038