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I've done it both ways with an without adex.  I have been on and off TRT for over 2 years.  I don't feel any different if my E2 is 17 or if it is 40.  I do recall Dr Rand saying that elevated estrogens may lead to prostate cancer long term so it is best to control this level and he advocated (at least at one time) keeping E2 in that range although many of his strength athletes felt better at 35 E2.  I subscribe to this theory wrong or right.  It might not matter 17 or 40, but I don't want it to be 80.  I'm not a heavy aromatizer bc my T:E2 ration with no AI tends to be about 30.