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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How Many Milligrams Of Testosterone Do Men Naturally Produce?
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<blockquote data-quote="Cataceous" data-source="post: 243519" data-attributes="member: 38109"><p>Here's the context: This applies to men on TRT who are using methods that provide stable testosterone levels, which include injecting testosterone cypionate relatively frequently. Endogenous testosterone does vary in men throughout the day, but typically the morning peak is used as the representative value. It's hypothesized that the peak level has some independent effects. If a guy on TRT with static levels wants to target a particular level of testosterone to match the peak seen in endogenous production then he needs to use a little more testosterone. To illustrate: Suppose a guy naturally has daily peak total testosterone of 600 ng/dL, trough of 400 ng/dL, and an overall average of 500 ng/dL. Further suppose that his total daily production is 6 mg of testosterone. If this guy goes on TRT and has static levels then how much testosterone must he take to match his natural peak of 600 ng/dL? On TRT, his peak, trough and average values are all the same. The daily production rate or dose rate of testosterone drives the average level. Therefore, on TRT this guy must take roughly 600/500 * 6 mg = 7.2 mg testosterone daily to achieve a constant level of 600 ng/dL. The calculation should actually be based on free testosterone rather than total, because it seems likely that free testosterone, more than total, is linear with dose.</p><p></p><p>It might also be hypothesized that there are some benefits in having diurnal variation in testosterone. If so these are defeated by having relatively constant levels. --insert usual plug for daily propionate blend here--</p></blockquote><p></p>
[QUOTE="Cataceous, post: 243519, member: 38109"] Here's the context: This applies to men on TRT who are using methods that provide stable testosterone levels, which include injecting testosterone cypionate relatively frequently. Endogenous testosterone does vary in men throughout the day, but typically the morning peak is used as the representative value. It's hypothesized that the peak level has some independent effects. If a guy on TRT with static levels wants to target a particular level of testosterone to match the peak seen in endogenous production then he needs to use a little more testosterone. To illustrate: Suppose a guy naturally has daily peak total testosterone of 600 ng/dL, trough of 400 ng/dL, and an overall average of 500 ng/dL. Further suppose that his total daily production is 6 mg of testosterone. If this guy goes on TRT and has static levels then how much testosterone must he take to match his natural peak of 600 ng/dL? On TRT, his peak, trough and average values are all the same. The daily production rate or dose rate of testosterone drives the average level. Therefore, on TRT this guy must take roughly 600/500 * 6 mg = 7.2 mg testosterone daily to achieve a constant level of 600 ng/dL. The calculation should actually be based on free testosterone rather than total, because it seems likely that free testosterone, more than total, is linear with dose. It might also be hypothesized that there are some benefits in having diurnal variation in testosterone. If so these are defeated by having relatively constant levels. --insert usual plug for daily propionate blend here-- [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How Many Milligrams Of Testosterone Do Men Naturally Produce?
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