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I saw a podcast with Dr Kominiarek a few days ago and he said TRT doesn't work for everybody and he can put guys in one of 4 categories: one, they feel great and its the best thing they've ever done; two, they feel subtly better; three, they don't feel anything from it; four, they feel worse and have a bad reaction and side effects that are intolerable.  One thing I like about him was his honesty in admitting no one knows why this happens, and he speculates it is related to genetic issues that we haven't come to understand yet.