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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
How long for TRT to shut down spermatogenesis
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<blockquote data-quote="madman" data-source="post: 141879" data-attributes="member: 13851"><p>When starting trt use of exogenous testosterone will result in shutdown of ones hpta within 4-6 weeks and will have a negative effect on spermatogenesis and fertility <strong><span style="color: rgb(184, 49, 47)">within 4 months </span></strong>of use.</p><p></p><p></p><p></p><p><span style="font-size: 22px"><strong>How testosterone inhibits spermatogenesis and fertility</strong></span></p><p></p><p><span style="color: rgb(184, 49, 47)"><span style="font-size: 18px"><strong>Mechanism of action</strong></span></span></p><p>Testosterone inhibits both GnRH and gonadotropin secretion. Exogenous administration of synthetic testosterone results in negative feedback on the hypothalamic-pituitary axis, inhibiting GnRH, leading to inhibition of FSH and LH production. As a result, intratesticular testosterone levels (ITT) and overall testosterone production decrease. Exogenous testosterone therapies can suppress ITT production to such a degree that spermatogenesis can be dramatically compromised at ITT concentrations to less than 20 ng/mL, even resulting in azoospermia (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708215/#r9" target="_blank">9</a>-<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708215/#r11" target="_blank">11</a>) (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708215/figure/f3/" target="_blank"><em>Figure 3</em></a>).</p><p></p><p></p><p></p><p></p><p></p><p>[ATTACH=full]7001[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 141879, member: 13851"] When starting trt use of exogenous testosterone will result in shutdown of ones hpta within 4-6 weeks and will have a negative effect on spermatogenesis and fertility [B][COLOR=rgb(184, 49, 47)]within 4 months [/COLOR][/B]of use. [SIZE=22px][B]How testosterone inhibits spermatogenesis and fertility[/B][/SIZE] [COLOR=rgb(184, 49, 47)][SIZE=18px][B]Mechanism of action[/B][/SIZE][/COLOR] Testosterone inhibits both GnRH and gonadotropin secretion. Exogenous administration of synthetic testosterone results in negative feedback on the hypothalamic-pituitary axis, inhibiting GnRH, leading to inhibition of FSH and LH production. As a result, intratesticular testosterone levels (ITT) and overall testosterone production decrease. Exogenous testosterone therapies can suppress ITT production to such a degree that spermatogenesis can be dramatically compromised at ITT concentrations to less than 20 ng/mL, even resulting in azoospermia ([URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708215/#r9']9[/URL]-[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708215/#r11']11[/URL]) ([URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708215/figure/f3/'][I]Figure 3[/I][/URL]). [ATTACH=full]7001[/ATTACH] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
How long for TRT to shut down spermatogenesis
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