ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How long does it take to get to pre TRT levels!?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 150196" data-attributes="member: 13851"><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/23543029#" target="_blank">Endocr Pract.</a> 2013 Mar-Apr;19(2):236-42. doi: 10.4158/EP12113.OR.</p><p><span style="font-size: 26px"><strong>Are there variances of calculated free testosterone attributed to variations in albumin and sex hormone-binding globulin concentrations in men?</strong></span></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Guay%20AT%5BAuthor%5D&cauthor=true&cauthor_uid=23543029" target="_blank">Guay AT</a>1, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Traish%20AM%5BAuthor%5D&cauthor=true&cauthor_uid=23543029" target="_blank">Traish AM</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Hislop-Chestnut%20DT%5BAuthor%5D&cauthor=true&cauthor_uid=23543029" target="_blank">Hislop-Chestnut DT</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Doros%20G%5BAuthor%5D&cauthor=true&cauthor_uid=23543029" target="_blank">Doros G</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Gawoski%20JM%5BAuthor%5D&cauthor=true&cauthor_uid=23543029" target="_blank">Gawoski JM</a>.</p><p><span style="font-size: 18px"><strong><a href="https://www.ncbi.nlm.nih.gov/pubmed/23543029#" target="_blank">Author information</a></strong></span></p><p></p><p><span style="font-size: 18px"><strong>Abstract</strong></span></p><p></p><p><strong>OBJECTIVE:</strong></p><p>Calculated free testosterone (cFT) is determined from total testosterone (TT), sex hormone binding globulin (SHBG), and albumin (Alb) levels using mathematical formulae. Variations in cFT due to changes in SHBG or Alb have not been investigated. We evaluated potential cFT variances determined with fixed Alb (4.3 g/dL) and measured Alb, and the point at which low SHBG and Alb combinations produced significant cFT variance.</p><p></p><p><strong>METHOD:</strong></p><p>We analyzed <strong><span style="color: rgb(184, 49, 47)">11,176</span> <span style="color: rgb(184, 49, 47)">data points from</span> <span style="color: rgb(184, 49, 47)">5,797 men</span>.</strong> <span style="color: rgb(44, 130, 201)"><strong>cFT values with fixed</strong></span><span style="color: rgb(184, 49, 47)"><strong> versus </strong></span><span style="color: rgb(44, 130, 201)"><strong>actual Alb values were evaluated and compared</strong></span>.<strong> cFT levels were theoretically determined for <span style="color: rgb(184, 49, 47)">all possible combinations of TT, SHBG</span>, and</strong> <strong><span style="color: rgb(44, 130, 201)">Alb</span> (<span style="color: rgb(184, 49, 47)">8,343,552 combinations</span>)</strong>. Agreement between the 2 measures was assessed with Lin's concordance coefficient.</p><p></p><p><strong>RESULTS:</strong></p><p>Mean Alb was 4.06 ± 0.32 g/dL. Mean SHBG was 39.0 ± 23.6 nmol/L.<strong><span style="color: rgb(184, 49, 47)"> A fixed Alb of </span><span style="color: rgb(44, 130, 201)">4.3 g/dL</span><span style="color: rgb(184, 49, 47)"> did not produce significant variance</span> for most cFT evaluations. <span style="color: rgb(184, 49, 47)">Accuracy decreased when </span><span style="color: rgb(44, 130, 201)">Alb was ≤3.5 g/dL</span><span style="color: rgb(184, 49, 47)"> in combination with </span><span style="color: rgb(44, 130, 201)">SHBG ≤30 nmol/L</span><span style="color: rgb(184, 49, 47)">,</span> and this occurred in 1.2% of all data points.</strong></p><p></p><p><strong>CONCLUSION:</strong></p><p><strong>A <span style="color: rgb(44, 130, 201)">fixed Alb of 4.3 g/dL</span> is acceptable for most clinical evaluations. <span style="color: rgb(44, 130, 201)">If Alb is ≤3.5 g/dL and SHBG is ≤30 nmol/L, the variance increases</span><span style="color: rgb(184, 49, 47)">, and a free testosterone (FT) measurement by </span><span style="color: rgb(251, 160, 38)">equilibrium dialysis </span><span style="color: rgb(184, 49, 47)">is warranted for </span></strong><span style="color: rgb(251, 160, 38)"><strong>better accuracy</strong></span><strong><span style="color: rgb(184, 49, 47)">.</span></strong></p></blockquote><p></p>
[QUOTE="madman, post: 150196, member: 13851"] [URL='https://www.ncbi.nlm.nih.gov/pubmed/23543029#']Endocr Pract.[/URL] 2013 Mar-Apr;19(2):236-42. doi: 10.4158/EP12113.OR. [SIZE=26px][B]Are there variances of calculated free testosterone attributed to variations in albumin and sex hormone-binding globulin concentrations in men?[/B][/SIZE] [URL='https://www.ncbi.nlm.nih.gov/pubmed/?term=Guay%20AT%5BAuthor%5D&cauthor=true&cauthor_uid=23543029']Guay AT[/URL]1, [URL='https://www.ncbi.nlm.nih.gov/pubmed/?term=Traish%20AM%5BAuthor%5D&cauthor=true&cauthor_uid=23543029']Traish AM[/URL], [URL='https://www.ncbi.nlm.nih.gov/pubmed/?term=Hislop-Chestnut%20DT%5BAuthor%5D&cauthor=true&cauthor_uid=23543029']Hislop-Chestnut DT[/URL], [URL='https://www.ncbi.nlm.nih.gov/pubmed/?term=Doros%20G%5BAuthor%5D&cauthor=true&cauthor_uid=23543029']Doros G[/URL], [URL='https://www.ncbi.nlm.nih.gov/pubmed/?term=Gawoski%20JM%5BAuthor%5D&cauthor=true&cauthor_uid=23543029']Gawoski JM[/URL]. [SIZE=18px][B][URL='https://www.ncbi.nlm.nih.gov/pubmed/23543029#']Author information[/URL][/B][/SIZE] [SIZE=18px][B]Abstract[/B][/SIZE] [B]OBJECTIVE:[/B] Calculated free testosterone (cFT) is determined from total testosterone (TT), sex hormone binding globulin (SHBG), and albumin (Alb) levels using mathematical formulae. Variations in cFT due to changes in SHBG or Alb have not been investigated. We evaluated potential cFT variances determined with fixed Alb (4.3 g/dL) and measured Alb, and the point at which low SHBG and Alb combinations produced significant cFT variance. [B]METHOD:[/B] We analyzed [B][COLOR=rgb(184, 49, 47)]11,176[/COLOR] [COLOR=rgb(184, 49, 47)]data points from[/COLOR] [COLOR=rgb(184, 49, 47)]5,797 men[/COLOR].[/B] [COLOR=rgb(44, 130, 201)][B]cFT values with fixed[/B][/COLOR][COLOR=rgb(184, 49, 47)][B] versus [/B][/COLOR][COLOR=rgb(44, 130, 201)][B]actual Alb values were evaluated and compared[/B][/COLOR].[B] cFT levels were theoretically determined for [COLOR=rgb(184, 49, 47)]all possible combinations of TT, SHBG[/COLOR], and[/B] [B][COLOR=rgb(44, 130, 201)]Alb[/COLOR] ([COLOR=rgb(184, 49, 47)]8,343,552 combinations[/COLOR])[/B]. Agreement between the 2 measures was assessed with Lin's concordance coefficient. [B]RESULTS:[/B] Mean Alb was 4.06 ± 0.32 g/dL. Mean SHBG was 39.0 ± 23.6 nmol/L.[B][COLOR=rgb(184, 49, 47)] A fixed Alb of [/COLOR][COLOR=rgb(44, 130, 201)]4.3 g/dL[/COLOR][COLOR=rgb(184, 49, 47)] did not produce significant variance[/COLOR] for most cFT evaluations. [COLOR=rgb(184, 49, 47)]Accuracy decreased when [/COLOR][COLOR=rgb(44, 130, 201)]Alb was ≤3.5 g/dL[/COLOR][COLOR=rgb(184, 49, 47)] in combination with [/COLOR][COLOR=rgb(44, 130, 201)]SHBG ≤30 nmol/L[/COLOR][COLOR=rgb(184, 49, 47)],[/COLOR] and this occurred in 1.2% of all data points.[/B] [B]CONCLUSION: A [COLOR=rgb(44, 130, 201)]fixed Alb of 4.3 g/dL[/COLOR] is acceptable for most clinical evaluations. [COLOR=rgb(44, 130, 201)]If Alb is ≤3.5 g/dL and SHBG is ≤30 nmol/L, the variance increases[/COLOR][COLOR=rgb(184, 49, 47)], and a free testosterone (FT) measurement by [/COLOR][COLOR=rgb(251, 160, 38)]equilibrium dialysis [/COLOR][COLOR=rgb(184, 49, 47)]is warranted for [/COLOR][/B][COLOR=rgb(251, 160, 38)][B]better accuracy[/B][/COLOR][B][COLOR=rgb(184, 49, 47)].[/COLOR][/B] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How long does it take to get to pre TRT levels!?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top