ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How long after the T injection are T levels the highest?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Cataceous" data-source="post: 152727" data-attributes="member: 38109"><p>Please read the rest of the other thread. It clears up some of these misconceptions. Most important, these tubs can never drain completely, which is a consequence of having the drain flow proportional to water height and to drain size. There is always going to be a non-zero water height in both tubs. As a result, at steady state we can write:</p><p></p><p><strong>k * water_height(lower_tub) * drain_size(lower_tub) = flow_rate = constant</strong></p><p></p><p>which is modeling:</p><p></p><p>free_T = k1 * total_T * f(SHBG)</p><p><span style="font-size: 14px">k2 * free_T = </span><strong><span style="font-size: 14px">k3 * total_T * f(SHBG) = MCR<span style="font-size: 9px">T</span> = constant</span></strong></p><p></p><p>Making free T linear in total T is an assumption, but models show this to be fairly reasonable at a fixed SHBG. MCR<span style="font-size: 9px">T</span> is the metabolic clearance rate of testosterone. The analogous parameters are:</p><p><strong>water_height ~ <strong><span style="font-size: 14px">total_T</span></strong></strong></p><p><strong>drain_size ~ <strong><span style="font-size: 14px">f(SHBG)</span></strong></strong></p><p><strong>flow_rate ~ <strong><span style="font-size: 14px">MCR<span style="font-size: 9px">T</span></span></strong></strong></p><p></p><p></p><p></p><p>Show me the math that makes this possible. You're claiming a change in the effective half-life of testosterone. This will take some extreme gymnastics, because the release of testosterone from the injected depot is the same regardless of SHBG. Somehow, with low SHBG you have to make the MCR<span style="font-size: 9px">T</span> lower with high total T and higher with low total T, which seems completely non-physical.</p><p></p><p></p><p></p><p>The low-SHBG guys cannot "expel" testosterone more quickly, because the rate is limited by the same slow release from the injected depot. The effect is to lower total testosterone. I have directly observed this myself, having recently crashed SHBG from 30 nMol/L to 10, and find the same dose of testosterone now produces much lower total serum testosterone.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 152727, member: 38109"] Please read the rest of the other thread. It clears up some of these misconceptions. Most important, these tubs can never drain completely, which is a consequence of having the drain flow proportional to water height and to drain size. There is always going to be a non-zero water height in both tubs. As a result, at steady state we can write: [B]k * water_height(lower_tub) * drain_size(lower_tub) = flow_rate = constant[/B] which is modeling: free_T = k1 * total_T * f(SHBG) [SIZE=14px]k2 * free_T = [/SIZE][B][SIZE=14px]k3 * total_T * f(SHBG) = MCR[SIZE=9px]T[/SIZE] = constant[/SIZE][/B] Making free T linear in total T is an assumption, but models show this to be fairly reasonable at a fixed SHBG. MCR[SIZE=9px]T[/SIZE] is the metabolic clearance rate of testosterone. The analogous parameters are: [B]water_height ~ [B][SIZE=14px]total_T[/SIZE][/B] drain_size ~ [B][SIZE=14px]f(SHBG)[/SIZE][/B] flow_rate ~ [B][SIZE=14px]MCR[SIZE=9px]T[/SIZE][/SIZE][/B][/B] [SIZE=14px][/SIZE] Show me the math that makes this possible. You're claiming a change in the effective half-life of testosterone. This will take some extreme gymnastics, because the release of testosterone from the injected depot is the same regardless of SHBG. Somehow, with low SHBG you have to make the MCR[SIZE=9px]T[/SIZE] lower with high total T and higher with low total T, which seems completely non-physical. The low-SHBG guys cannot "expel" testosterone more quickly, because the rate is limited by the same slow release from the injected depot. The effect is to lower total testosterone. I have directly observed this myself, having recently crashed SHBG from 30 nMol/L to 10, and find the same dose of testosterone now produces much lower total serum testosterone. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How long after the T injection are T levels the highest?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top