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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How long after the T injection are T levels the highest?
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<blockquote data-quote="antelopers" data-source="post: 152724" data-attributes="member: 38214"><p>Ok but using your tub of water analogy, assuming low shbg in the bottom bathtub having a bigger drain - whatever is being released into the bottom tub is being expelled very quickly. No matter how much you add to the first bathtub, it will be expelled as soon as it reaches the bottom one if the bottom drain is bigger. It wouldn't hanging around pooling in the bottom at the same rate if the drain was bigger. Which is what injections aim for- a supply of serum testosterone in your system that is bound and then used as it releases from shbg and albumin at a reasonable rate (the bottom drain). So if it's not being bound enough, that means it's expelling too quickly.</p><p></p><p>The solution then, would be to add multiple bathtubs on the top to increase the amount to saturate the bottom tub until you overcame the speed of the drain, while simultaneously preventing too much unbound t in the system at once which can lead to rapid aromatization. Which would be the equivalent of having multiple smaller depots spaced out on say a daily basis. Another depot starts releasing before bottom tub expels everything from the first.</p><p></p><p>You can see this from low vs normal shbg guys who test peak and trough. The low shbg guys have a lower trough after their peak and have to compensate by injecting more frequently if they want that total serum T to be as high as someone with low shbg.</p><p></p><p>That is also assuming that an ester in a Depot has a flat release rate, it doesn't. It's at it's maximum somewhere around 24-48 hours normally if you look at cypionate pharmacokinetics, and then starts dropping off pretty quickly as the surface area of the depot quickly decreases. Again, looking at it this way, if a low shbg guy is expelling the testosterone entering his system quickly, injections every 48 hours would make sense to give the new depot time to release and start rising before the other one falls too much to overcompensate for the fact that what is being released into the bloodstream is rapidly expelled. If they have low shbg, anything being released from the depot is being expelled too quickly to give a more relatively "stable" supply of Testosterone in the blood that naturally unbinds at the rate it would in someone with normal shbg.</p></blockquote><p></p>
[QUOTE="antelopers, post: 152724, member: 38214"] Ok but using your tub of water analogy, assuming low shbg in the bottom bathtub having a bigger drain - whatever is being released into the bottom tub is being expelled very quickly. No matter how much you add to the first bathtub, it will be expelled as soon as it reaches the bottom one if the bottom drain is bigger. It wouldn't hanging around pooling in the bottom at the same rate if the drain was bigger. Which is what injections aim for- a supply of serum testosterone in your system that is bound and then used as it releases from shbg and albumin at a reasonable rate (the bottom drain). So if it's not being bound enough, that means it's expelling too quickly. The solution then, would be to add multiple bathtubs on the top to increase the amount to saturate the bottom tub until you overcame the speed of the drain, while simultaneously preventing too much unbound t in the system at once which can lead to rapid aromatization. Which would be the equivalent of having multiple smaller depots spaced out on say a daily basis. Another depot starts releasing before bottom tub expels everything from the first. You can see this from low vs normal shbg guys who test peak and trough. The low shbg guys have a lower trough after their peak and have to compensate by injecting more frequently if they want that total serum T to be as high as someone with low shbg. That is also assuming that an ester in a Depot has a flat release rate, it doesn't. It's at it's maximum somewhere around 24-48 hours normally if you look at cypionate pharmacokinetics, and then starts dropping off pretty quickly as the surface area of the depot quickly decreases. Again, looking at it this way, if a low shbg guy is expelling the testosterone entering his system quickly, injections every 48 hours would make sense to give the new depot time to release and start rising before the other one falls too much to overcompensate for the fact that what is being released into the bloodstream is rapidly expelled. If they have low shbg, anything being released from the depot is being expelled too quickly to give a more relatively "stable" supply of Testosterone in the blood that naturally unbinds at the rate it would in someone with normal shbg. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How long after the T injection are T levels the highest?
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