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Rule of thumb is five half-lives to stabilize serum levels, which is around 10 days for anastrozole. But I'd extend that to at least two weeks for full effects on estradiol. That's a pretty large dose of anastrozole for just starting out and having estradiol only modestly elevated. I don't know if your doctor would condone self-compounding to create lower doses. Of course you can use a compounding pharmacy, but that gets expensive.

[QUOTE="Cataceous, post: 171607, member: 38109"] Rule of thumb is five half-lives to stabilize serum levels, which is around 10 days for anastrozole. But I'd extend that to at least two weeks for full effects on estradiol. That's a pretty large dose of anastrozole for just starting out and having estradiol only modestly elevated. I don't know if your doctor would condone self-compounding to create lower doses. Of course you can use a compounding pharmacy, but that gets expensive. [/QUOTE]