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Adex takes about 10 days to get to full strength in the body (steady state).  If you feel much better at three days, that is a sign you are on too high a dose which could eventually lead to too low of e2 levels. If you feel good in 24 hours, at 10 days your E2 will be way too low.  The idea with Adex is to take the absolute minimum dosage that takes away symptoms around day 10.  After that it is obviously a good idea to retest E2 to see where you are at.