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I've been speculating similarly about testosterone: What if peak levels of LH are important, independent of average levels? This would explain why such relatively high doses of hCG are needed to get the effects we want, which in turn increase the risk of side effects. Very crudely, at least, the numbers may reconcile. It's claimed that on a per-IU basis, hCG is six to eight times more potent than LH. Dr. Saya's case study on hCG suggests a response area-under-the-curve (AUC) of ~6 mIU/mL*days for a 500 IU injection. One study showed normal intratesticular testosterone would be achieved with injections of 300 IU every other day. This would translate to average serum levels of 1.8 mIU/mL. Applying a factor of six or so is supposed to give an LH equivalent—10.8 mIU/mL. And this figure corresponds pretty well with peak LH values reported in this work. It's pretty tenuous evidence, and much more would be needed to say if the idea really has merit.


TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

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Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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