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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
How can we predict efficacy of HCG plus testosterone on sperm production?
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<blockquote data-quote="Nelson Vergel" data-source="post: 140038" data-attributes="member: 3"><p><span style="font-size: 18px"><strong><a href="https://thslc-houston.primo.exlibrisgroup.com/discovery/fulldisplay?docid=wj10.1002/j.1939-4640.1981.tb00614.x&context=PC&vid=01TEXASHEALTH_HOUSTON:TMC_INST&lang=en&search_scope=MyInst_and_CI&adaptor=Primo%20Central&tab=Everything&query=any,contains,hcg%20progesterone%20men&offset=0" target="_blank">The Aging Leydig Cell: III. Gonadotropin Stimulation in Men</a></strong></span></p><p>Nankin, H. R. ; Lin, T. ; Murono, E. P. ; Osterman, J.</p><p>Journal of Andrology, 08 July 1981, Vol.2(4), pp.181-189</p><p></p><p></p><p></p><p>To assess the capacity of aging human Leydig cells to respond to intramuscular injection of hCG, six healthy men, 68 to 86 years old, and eight healthy younger subjects, 25 to 42 years old, were studied. After two control specimens, each subject was given hCG (40 IU/kg of body weight intramuscularly) at 0900 hours. Blood specimens were then obtained hourly for 6 hours and at 24, 48, and 72 hours. The younger men had higher control concentrations of testosterone ( < 0.05). <strong>Both groups demonstrated biphasic elevations of circulating testosterone and 170H‐progesterone with a nadir at 5 hours and 6 hours separating the rises.</strong> The early (1–6 hours) and late (24, 48, and 72 hours) testosterone and 170H‐progesterone responses to hCG were significantly lower in older men. The older men demonstrated significant estradiol increases at 3, 4, and 6 hours, while the younger group had a significant 2‐hour rise. However, the peak (24‐hour) estradiol rises were significantly greater in the younger men. We conclude that the aged Leydig cell demonstrates altered early (1–6 hours) and late(24, 48, and 72 hours) responses to intramuscular injection of hCG, as assessed by circulating concentrations of testosterone, 17OH‐progesterone, and estradiol.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 140038, member: 3"] [SIZE=18px][B][URL='https://thslc-houston.primo.exlibrisgroup.com/discovery/fulldisplay?docid=wj10.1002/j.1939-4640.1981.tb00614.x&context=PC&vid=01TEXASHEALTH_HOUSTON:TMC_INST&lang=en&search_scope=MyInst_and_CI&adaptor=Primo%20Central&tab=Everything&query=any,contains,hcg%20progesterone%20men&offset=0']The Aging Leydig Cell: III. Gonadotropin Stimulation in Men[/URL][/B][/SIZE] Nankin, H. R. ; Lin, T. ; Murono, E. P. ; Osterman, J. Journal of Andrology, 08 July 1981, Vol.2(4), pp.181-189 To assess the capacity of aging human Leydig cells to respond to intramuscular injection of hCG, six healthy men, 68 to 86 years old, and eight healthy younger subjects, 25 to 42 years old, were studied. After two control specimens, each subject was given hCG (40 IU/kg of body weight intramuscularly) at 0900 hours. Blood specimens were then obtained hourly for 6 hours and at 24, 48, and 72 hours. The younger men had higher control concentrations of testosterone ( < 0.05). [B]Both groups demonstrated biphasic elevations of circulating testosterone and 170H‐progesterone with a nadir at 5 hours and 6 hours separating the rises.[/B] The early (1–6 hours) and late (24, 48, and 72 hours) testosterone and 170H‐progesterone responses to hCG were significantly lower in older men. The older men demonstrated significant estradiol increases at 3, 4, and 6 hours, while the younger group had a significant 2‐hour rise. However, the peak (24‐hour) estradiol rises were significantly greater in the younger men. We conclude that the aged Leydig cell demonstrates altered early (1–6 hours) and late(24, 48, and 72 hours) responses to intramuscular injection of hCG, as assessed by circulating concentrations of testosterone, 17OH‐progesterone, and estradiol. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
How can we predict efficacy of HCG plus testosterone on sperm production?
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