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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How can testosterone affect cognitive performance?
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<blockquote data-quote="thyronine" data-source="post: 197613" data-attributes="member: 42067"><p>I've always been astonished at how poorly this point is conveyed by doctors and medicine in general.</p><p>The vast majority of men who start TRT are still under the assumption that it is simply replacing testosterone in isolation, or 'replacing what you should have had'.</p><p>The reality is anything but:</p><p>- partial (complete in some) shutdown of upstream steroids - all of which fulfil important functions independent of their conversion to testosterone; particularly in cognition, the topic at hand.</p><p>- altered HPA function via CRH / ACTH modulation, again with cortisol heavily implicated in cognition, assertiveness, etc.</p><p>- potential dopamine dysregulation, likely via the estrogen-induced rise in prolactin and serotonin, but it could just be testosterone itself since it's heavily involved in basolimbic regulation.</p><p>- raised HCT.</p><p>- disruption to diurnal variation / circadian rhythm.</p><p>- altered thyroid function.</p><p>The list could go on for a while. For men who're truly deficient the above are a worthy trade-off, but for someone with a fully functioning endocrine system who thinks going on TRT will make them 'optimal', the cost:benefit analysis is extrodindarly skewed towards the former.</p></blockquote><p></p>
[QUOTE="thyronine, post: 197613, member: 42067"] I've always been astonished at how poorly this point is conveyed by doctors and medicine in general. The vast majority of men who start TRT are still under the assumption that it is simply replacing testosterone in isolation, or 'replacing what you should have had'. The reality is anything but: - partial (complete in some) shutdown of upstream steroids - all of which fulfil important functions independent of their conversion to testosterone; particularly in cognition, the topic at hand. - altered HPA function via CRH / ACTH modulation, again with cortisol heavily implicated in cognition, assertiveness, etc. - potential dopamine dysregulation, likely via the estrogen-induced rise in prolactin and serotonin, but it could just be testosterone itself since it's heavily involved in basolimbic regulation. - raised HCT. - disruption to diurnal variation / circadian rhythm. - altered thyroid function. The list could go on for a while. For men who're truly deficient the above are a worthy trade-off, but for someone with a fully functioning endocrine system who thinks going on TRT will make them 'optimal', the cost:benefit analysis is extrodindarly skewed towards the former. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How can testosterone affect cognitive performance?
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