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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How Accurate Is The Online Tru-T Free Test. Calculator?
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<blockquote data-quote="madman" data-source="post: 236061" data-attributes="member: 13851"><p><strong><em>post #15/16</em></strong></p><p><a href="https://www.excelmale.com/forum/threads/role-of-shbg-in-the-free-hormone-hypothesis-and-the-relevance-of-free-testosterone-in-androgen-physiology.26218/" target="_blank">Role of SHBG in the free hormone hypothesis and the relevance of free testosterone in androgen physiology</a></p><p></p><p><strong>linear law-of-mass action (cFTV)</strong></p><p></p><p>When it comes to using any of the calculators for estimating free testosterone cFTV has been the go-to.</p><p></p><p>Already validated/revalidated against ED!</p><p></p><p>Been in use for over 2 decades and now it is being challenged.</p><p></p><p></p><p></p><p>This is coming from Fier's camp's most recent paper (posted in the link above).</p><p></p><p>They clearly state <u>for the time being</u>, as they are well aware there is still much going on behind the scenes.</p><p></p><p>Far from over!</p><p></p><p><strong><em>*In contrast we concluded that, although overestimating free T by 20–30%, the formula according to Vermeulen was independent of SHBG, total T, and albumin [221]. Taken into consideration the moderate bias level, but most importantly less influenced by the latter three variables, the <u>Vermeulen formula, for the time being, still appears to be the most robust approximation and deserves our recommendation as a free T calculator for clinical use</u></em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em>post #36</em></strong></p><p><a href="https://www.excelmale.com/forum/threads/tru-t-calculator-what-is-the-range.19213/page-2#post-228658" target="_blank">Tru T calculator - what is the range?</a></p><p></p><p><strong>ensemble allosteric model (cFTZ/TruTTM)</strong></p><p></p><p>Post #36 sums up where Bhasin and his team stand.</p><p></p><p>It has already been validated in Phase 1.</p><p></p><p></p><p></p><p></p><p><strong>My reply from the previous thread:</strong></p><p></p><p>Even then it still needs further validation which is going to happen during Phase II.</p><p></p><p>There has been an ongoing effort behind the scenes to provide further proof of the validity of the TruT™algorithm (cFTZ).</p><p></p><p>You and I let alone everyone in the know including top researchers in the field/medical community is waiting on the results/data from Phase II.</p><p></p><p></p><p><strong>Bhasin:</strong></p><p><strong></strong></p><p><strong><em>*the Vermeulen equation and others that assume a fixed Kd are just conceptually wrong and our data show it clearly that this model is completely wrong</em></strong></p><p><strong><em></em></strong></p><p><strong><em>*so the Vermeulen model or most of the linear equations underestimate free testosterone concentrations and the ensemble allosteric model (EAM) based upon our experimental data matches total testosterone within the range in which we have validated this</em></strong></p><p></p><p></p><p></p><p></p><p><em><strong><u>*In phase I studies, we demonstrated that the TruTTM algorithm provides accurate free T values that match those obtained using the equilibrium dialysis in healthy and hypogonadal men</u>. We have also shown that the binding parameters that have formed the basis of previous equations (e.g., Vermeulen) are incorrect, and that free T values derived using these equations deviate substantially from free T measured by equilibrium dialysis. <u>The phase I studies have led to the adoption of the TruTTM algorithm at several institutions</u>.</strong></em></p><p></p><p></p><p></p><p></p><p>Everyone keeps talking out of their ass yet the results /data from Phase II have not come out yet!</p><p></p><p><em><strong>*The<u> phase II program will continue the development of the TruTTM algorithm by validating it in common conditions characterized by altered SHBG concentrations</u>, such as obesity and aging (AIM 1), in healthy women across the menstrual cycle, and in women with PCOS (Aim 2).</strong> <strong><u>We will generate population-based reference ranges for free T (Aim 3)</u>. <u>Phase II also includes plans for the commercialization of the TruTTM algorithm using a HIPAA-compliant infrastructure for its clinical adoption</u></strong></em></p><p></p><p><strong><strong><em>*The phase II program will provide validation of the TruTTM algorithm in the two most common clinical indications for free T measurement - men suspected of hypogonadism and altered SHBG levels, and women with hyperandrogenic disorders</em></strong></strong></p></blockquote><p></p>
[QUOTE="madman, post: 236061, member: 13851"] [B][I]post #15/16[/I][/B] [URL='https://www.excelmale.com/forum/threads/role-of-shbg-in-the-free-hormone-hypothesis-and-the-relevance-of-free-testosterone-in-androgen-physiology.26218/']Role of SHBG in the free hormone hypothesis and the relevance of free testosterone in androgen physiology[/URL] [B]linear law-of-mass action (cFTV)[/B] When it comes to using any of the calculators for estimating free testosterone cFTV has been the go-to. Already validated/revalidated against ED! Been in use for over 2 decades and now it is being challenged. This is coming from Fier's camp's most recent paper (posted in the link above). They clearly state [U]for the time being[/U], as they are well aware there is still much going on behind the scenes. Far from over! [B][I]*In contrast we concluded that, although overestimating free T by 20–30%, the formula according to Vermeulen was independent of SHBG, total T, and albumin [221]. Taken into consideration the moderate bias level, but most importantly less influenced by the latter three variables, the [U]Vermeulen formula, for the time being, still appears to be the most robust approximation and deserves our recommendation as a free T calculator for clinical use[/U] post #36[/I][/B] [URL='https://www.excelmale.com/forum/threads/tru-t-calculator-what-is-the-range.19213/page-2#post-228658']Tru T calculator - what is the range?[/URL] [B]ensemble allosteric model (cFTZ/TruTTM)[/B] Post #36 sums up where Bhasin and his team stand. It has already been validated in Phase 1. [B]My reply from the previous thread:[/B] Even then it still needs further validation which is going to happen during Phase II. There has been an ongoing effort behind the scenes to provide further proof of the validity of the TruT™algorithm (cFTZ). You and I let alone everyone in the know including top researchers in the field/medical community is waiting on the results/data from Phase II. [B]Bhasin: [I]*the Vermeulen equation and others that assume a fixed Kd are just conceptually wrong and our data show it clearly that this model is completely wrong *so the Vermeulen model or most of the linear equations underestimate free testosterone concentrations and the ensemble allosteric model (EAM) based upon our experimental data matches total testosterone within the range in which we have validated this[/I][/B] [I][B][U]*In phase I studies, we demonstrated that the TruTTM algorithm provides accurate free T values that match those obtained using the equilibrium dialysis in healthy and hypogonadal men[/U]. We have also shown that the binding parameters that have formed the basis of previous equations (e.g., Vermeulen) are incorrect, and that free T values derived using these equations deviate substantially from free T measured by equilibrium dialysis. [U]The phase I studies have led to the adoption of the TruTTM algorithm at several institutions[/U].[/B][/I] Everyone keeps talking out of their ass yet the results /data from Phase II have not come out yet! [I][B]*The[U] phase II program will continue the development of the TruTTM algorithm by validating it in common conditions characterized by altered SHBG concentrations[/U], such as obesity and aging (AIM 1), in healthy women across the menstrual cycle, and in women with PCOS (Aim 2).[/B] [B][U]We will generate population-based reference ranges for free T (Aim 3)[/U]. [U]Phase II also includes plans for the commercialization of the TruTTM algorithm using a HIPAA-compliant infrastructure for its clinical adoption[/U][/B][/I] [B][B][I]*The phase II program will provide validation of the TruTTM algorithm in the two most common clinical indications for free T measurement - men suspected of hypogonadism and altered SHBG levels, and women with hyperandrogenic disorders[/I][/B][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How Accurate Is The Online Tru-T Free Test. Calculator?
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