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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Hope for an accurate method to determine Free Testosterone
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<blockquote data-quote="madman" data-source="post: 146675" data-attributes="member: 13851"><p>Of course accurate measurements of hormones are critical as SHBG/FT levels are of great importance to an effective trt protocol let alone overall health.</p><p></p><p>There is much more to SHBG than simply high/low levels. </p><p></p><p>Polymorphisms/mutants and some points noted below.</p><p></p><p></p><p></p><p></p><p></p><p><strong>A Reappraisal of Testosterone’s Binding in Circulation: Physiological and Clinical Implications</strong> </p><p></p><p><strong><span style="color: rgb(184, 49, 47)">Anna L. Goldman, Shalender Bhasin, Frederick C.W. Wu, Meenakshi Krishna, Alvin M. Matsumoto, and Ravi Jasuja </span></strong></p><p></p><p></p><p></p><p><strong>Multiple hypothetical mechanisms for the cellular uptake of testosterone and downstream signaling</strong></p><p></p><p>(a) the model depicting the "free" hormone hypothesis</p><p></p><p><strong><span style="color: rgb(184, 49, 47)">(b) the megalin dependent mode of testosterone entry</span></strong></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">(c) the SHBG receptor-testosterone system</span></strong></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">(d) steroid ligand-dependent interactions between SHBG and at least two matrix-associated proteins in the fibulin family</span></strong></p><p><a href="https://academic.oup.com/view-large/figure/94946825/er.2017-00025f4.tif" target="_blank"></a></p><p><a href="https://academic.oup.com/view-large/figure/94946825/er.2017-00025f4.tif" target="_blank"></a></p><p><a href="https://academic.oup.com/view-large/figure/94946825/er.2017-00025f4.tif" target="_blank">https://academic.oup.com/view-large/figure/94946825/er.2017-00025f4.tif</a> </p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><span style="font-size: 26px"><strong>Naturally Occurring Mutants Inform SHBG Structure and Function </strong></span></p><p><a href="https://www.excelmale.com/javascript%3A;" target="_blank">Tsung-Sheng Wu</a> <a href="https://www.excelmale.com/javascript%3A;" target="_blank">Geoffrey L. Hammond</a></p></blockquote><p></p>
[QUOTE="madman, post: 146675, member: 13851"] Of course accurate measurements of hormones are critical as SHBG/FT levels are of great importance to an effective trt protocol let alone overall health. There is much more to SHBG than simply high/low levels. Polymorphisms/mutants and some points noted below. [B]A Reappraisal of Testosterone’s Binding in Circulation: Physiological and Clinical Implications[/B] [B][COLOR=rgb(184, 49, 47)]Anna L. Goldman, Shalender Bhasin, Frederick C.W. Wu, Meenakshi Krishna, Alvin M. Matsumoto, and Ravi Jasuja [/COLOR][/B] [B]Multiple hypothetical mechanisms for the cellular uptake of testosterone and downstream signaling[/B] (a) the model depicting the "free" hormone hypothesis [B][COLOR=rgb(184, 49, 47)](b) the megalin dependent mode of testosterone entry[/COLOR][/B] [B][COLOR=rgb(184, 49, 47)](c) the SHBG receptor-testosterone system[/COLOR][/B] [B][COLOR=rgb(184, 49, 47)](d) steroid ligand-dependent interactions between SHBG and at least two matrix-associated proteins in the fibulin family[/COLOR][/B] [URL='https://academic.oup.com/view-large/figure/94946825/er.2017-00025f4.tif'] https://academic.oup.com/view-large/figure/94946825/er.2017-00025f4.tif[/URL] [SIZE=26px][B]Naturally Occurring Mutants Inform SHBG Structure and Function [/B][/SIZE] [URL='https://www.excelmale.com/javascript%3A;']Tsung-Sheng Wu[/URL] [URL='https://www.excelmale.com/javascript%3A;']Geoffrey L. Hammond[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Hope for an accurate method to determine Free Testosterone
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