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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
HMG (Human Menopausal Gonadotropin) Vrs HCG (Human Chorionic Gonadotropin) - What’s the difference?
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<blockquote data-quote="madman" data-source="post: 276907" data-attributes="member: 13851"><p>Take home points here!</p><p></p><p></p><p><em><strong>*</strong></em><strong><em>Human menopausal gonadotropin contains both LH- and FSH-activity. However, a <u>dose that provides adequate FSH activity does not maintain Leydig cell function because the LH activity is low</u>.</em> <em>Thus a <u>combination</u> with hCG is required to achieve fertility</em></strong></p><p><strong><em></em></strong></p><p><strong><em>*Although hMG has both FSH and LH activity, <u>FSH activity predominates, and LH activity is so low</u> that fertility requires a <u>combination</u> of hCG and hMG.</em></strong></p><p><strong><em></em></strong></p><p><strong><em>*</em></strong><em><strong>In some countries, a range of FSH formulations is currently accessible. <u>FSH has traditionally been given in the form of hMG</u>, obtained from postmenopausal women’s urine.</strong></em></p><p></p><p></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/threads/restoring-spermatogenesis-in-hypogonadotrophic-hypogonadism.26657/[/URL]</p><p></p><p><strong>*</strong><em><strong>The findings suggest that <u>normal qualitative and quantitative sperm production is best maintained in the presence of both FSH- and LH-induced testosterone secretion</u>. Human chorionic gonadotrophin (hCG) in conjunction with FSH is a common regimen for inducing spermatogenesis</strong></em></p><p></p><p><strong>*<em><strong>Although <u>hMG has both FSH and LH activity, FSH activity predominates, and LH activity is so low</u> that fertility requires a <u>combination of hCG and hMG</u></strong></em></strong></p><p></p><p><em><strong>*More recently, <u>highly pure urinary FSH preparations have been created, with higher specific activity than hMG</u>. <u>Recombinant human FSH formulations have greater purity and specific activity than any urinary preparation</u> and <u>no inherent LH activity</u></strong></em></p><p></p><p><strong>*<em><strong>Typically, hCG alone at a dose of 1000 IU on alternate days or twice weekly is usually used to start gonadotrophin therapy, with the dose titrated based on trough testosterone levels and testicular development</strong></em></strong></p><p><strong></strong></p><p><strong>*<em>Due to <u>residual FSH secretion</u>, spermatogenesis can be begun with <u>hCG alone in most individuals with bigger testes at baseline</u></em></strong></p><p><strong></strong></p><p><strong>*<em>Once there is a plateau in the response to hCG, which typically occurs at around 6 months, t<u>herapy with FSH (in one of the three forms described above)</u> should be added at a <u>dose of 75 IU on 3 days per week</u>. If sperm output and testicular growth remain suboptimal, the <u>dose of FSH can be gradually increased to 150 IU daily</u></em></strong></p><p></p><p></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/threads/has-anyone-had-success-in-restoring-fertility-with-fsh.26677/#post-241647[/URL]</p><p></p><p></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/threads/hcg-hmg-therapy-once-a-week-for-spermatogenesis-in-hypogonadotropic-hypogonadism.26071/[/URL]</p><p></p><p><em><strong>*Studies have confirmed that the <u>combined therapy of human chorionic gonadotropin (HCG) and human menopausal gonadotropin (HMG), 2 or 3 times a week</u>, had an overall success rate of 75% to 85% in achieving spermatogenesis.5-7 <u>No guidelines on the regimens of gonadotropin therapy have been agreed upon</u>. <u>Typical doses for HCG vary from 500 to 2500 IU, whereas HMG varies from 75 to 225 IU two to three times a week</u>.8-10</strong></em></p><p></p><p></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/threads/fsh-and-hcg-dual-therapy-may-result-in-the-more-rapid-recovery-of-sperm-to-the-ejaculate.22230/[/URL]</p><p></p><p><strong>Conclusions</strong></p><p></p><p><em><strong>Our results reiterate that <u>FSH in combination with hCG may be considered as an alternative to a combination of hCG and clomiphene</u> in the treatment of testosterone-induced azoospermia.</strong> <strong><em><u>FSH and hCG dual therapy may result in the more rapid recovery of sperm to the ejaculate being three times faster in the FSH group</u>. Additionally, patients who have failed dual therapy with hCG and clomiphene should be considered for subsequent FSH.</em></strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 276907, member: 13851"] Take home points here! [I][B]*[/B][/I][B][I]Human menopausal gonadotropin contains both LH- and FSH-activity. However, a [U]dose that provides adequate FSH activity does not maintain Leydig cell function because the LH activity is low[/U].[/I] [I]Thus a [U]combination[/U] with hCG is required to achieve fertility *Although hMG has both FSH and LH activity, [U]FSH activity predominates, and LH activity is so low[/U] that fertility requires a [U]combination[/U] of hCG and hMG. *[/I][/B][I][B]In some countries, a range of FSH formulations is currently accessible. [U]FSH has traditionally been given in the form of hMG[/U], obtained from postmenopausal women’s urine.[/B][/I] [URL unfurl="true"]https://www.excelmale.com/threads/restoring-spermatogenesis-in-hypogonadotrophic-hypogonadism.26657/[/URL] [B]*[/B][I][B]The findings suggest that [U]normal qualitative and quantitative sperm production is best maintained in the presence of both FSH- and LH-induced testosterone secretion[/U]. Human chorionic gonadotrophin (hCG) in conjunction with FSH is a common regimen for inducing spermatogenesis[/B][/I] [B]*[I][B]Although [U]hMG has both FSH and LH activity, FSH activity predominates, and LH activity is so low[/U] that fertility requires a [U]combination of hCG and hMG[/U][/B][/I][/B] [I][B]*More recently, [U]highly pure urinary FSH preparations have been created, with higher specific activity than hMG[/U]. [U]Recombinant human FSH formulations have greater purity and specific activity than any urinary preparation[/U] and [U]no inherent LH activity[/U][/B][/I] [B]*[I][B]Typically, hCG alone at a dose of 1000 IU on alternate days or twice weekly is usually used to start gonadotrophin therapy, with the dose titrated based on trough testosterone levels and testicular development[/B][/I] *[I]Due to [U]residual FSH secretion[/U], spermatogenesis can be begun with [U]hCG alone in most individuals with bigger testes at baseline[/U][/I] *[I]Once there is a plateau in the response to hCG, which typically occurs at around 6 months, t[U]herapy with FSH (in one of the three forms described above)[/U] should be added at a [U]dose of 75 IU on 3 days per week[/U]. If sperm output and testicular growth remain suboptimal, the [U]dose of FSH can be gradually increased to 150 IU daily[/U][/I][/B] [URL unfurl="true"]https://www.excelmale.com/threads/has-anyone-had-success-in-restoring-fertility-with-fsh.26677/#post-241647[/URL] [URL unfurl="true"]https://www.excelmale.com/threads/hcg-hmg-therapy-once-a-week-for-spermatogenesis-in-hypogonadotropic-hypogonadism.26071/[/URL] [I][B]*Studies have confirmed that the [U]combined therapy of human chorionic gonadotropin (HCG) and human menopausal gonadotropin (HMG), 2 or 3 times a week[/U], had an overall success rate of 75% to 85% in achieving spermatogenesis.5-7 [U]No guidelines on the regimens of gonadotropin therapy have been agreed upon[/U]. [U]Typical doses for HCG vary from 500 to 2500 IU, whereas HMG varies from 75 to 225 IU two to three times a week[/U].8-10[/B][/I] [URL unfurl="true"]https://www.excelmale.com/threads/fsh-and-hcg-dual-therapy-may-result-in-the-more-rapid-recovery-of-sperm-to-the-ejaculate.22230/[/URL] [B]Conclusions[/B] [I][B]Our results reiterate that [U]FSH in combination with hCG may be considered as an alternative to a combination of hCG and clomiphene[/U] in the treatment of testosterone-induced azoospermia.[/B] [B][I][U]FSH and hCG dual therapy may result in the more rapid recovery of sperm to the ejaculate being three times faster in the FSH group[/U]. Additionally, patients who have failed dual therapy with hCG and clomiphene should be considered for subsequent FSH.[/I][/B][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
HMG (Human Menopausal Gonadotropin) Vrs HCG (Human Chorionic Gonadotropin) - What’s the difference?
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