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My 'success' with 250 mg, sublingual, lasted one day. One rock hard erection in the evening.  After that, my sleep worsened and I became extremely irritable, similar to my experience with arginine.  The irritability lasted three days.  Scary for me, with bipolar illness.  I'm back self-treating with desiccated thyroid in hopes of establishing mood stability, sleep stability and erectile function.  Playing a long game, since I have to slowly titrate.