Histamine has been my bane since I was a child. Seasonal allergies, as well as food sensitivities. But when I began to think of histamine as related to sexual function, I recall when we lived in Maryland. During spring, when the pollen was high, my libido/erectile function went into overdrive, as well as being hypomanic(Also have Tourette's Syndrome and was ticcing like a machine gun). I worked as a courier, so I was driving around all day and seeing/interacting with women. Intensely horny! My wife was 'once a week is enough'. Jerking off everyday. Tempted to hook up with someone. My brain was on fire. Vitamin C never touched my histadelia, and I'd been taking several thousand milligrams, daily, since my early 20's. Another histamine/sexual function experience when I went to Miami in 2003 to visit family and friends. I'd gotten into eating raw honey and was eating spoonfuls everyday. Libido went up, as did erectile function, which was still okay. When I relapsed back into bipolar in mid 2004, my life and sexual function began to crater and that's where I've been stuck, even with testosterone. Recently added 25 mg of DHEA every morning. It's helped relieve my depression.
Histamine has functions in the brain. Read many abstracts and a few articles on it. There's H1, H2,(respriatory/gastro) H3 and H4, the latter two seeming to be exclusive to the brain. I've tried manipulating dopamine for ED,including being prescribed cabergoline by my urologist. Didn't find it helpful, nor was B6(P5P). Read the late Dr. Carl Pfieffer's books and his experiences with patients with low and high histamine. I used to fit most of the profile of histadelia; Couldn't gain weight, OCD/tics, poor sleep, easy orgasms, obsessed with sex(not on his list but fits with histadelia, IMO). Even though high histamine gave me an intense itch in the brain that I couldn't scratch, I felt alive, vital and, importantly, was sexually functional. Trying L-Histidine, sublingual. Started this morning, opening a 500 mg capsule and taking 250 mg. I always say I'll take it low and slow, then abandon that for balls to the wall. But I'll try to be restrained as I look for anything, negative or positive, from this latest experiment.
