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Crazy how this study demonstrates that higher IGF-1 is associated with multiple-domain cognitive impairment. I personally have extremely low IGF (~80 ng/ml) without rHGH. When I am not taking HGH my memory declines, cognitive horsepower decreases sharply, and creativity is diminished. When I am consistently on my prescription of 2 IU HGH daily, my cognitive function is excellent. I have not had time to read through this study thoroughly, but just from the abstract it would seem that this study would suggest the opposite to be true, as my IGF-1 was lower my cognitive function should be higher. Perhaps I am interpreting it incorrectly.

[QUOTE="DS3, post: 179769, member: 18514"] Crazy how this study demonstrates that higher IGF-1 is associated with multiple-domain cognitive impairment. I personally have extremely low IGF (~80 ng/ml) without rHGH. When I am not taking HGH my memory declines, cognitive horsepower decreases sharply, and creativity is diminished. When I am consistently on my prescription of 2 IU HGH daily, my cognitive function is excellent. I have not had time to read through this study thoroughly, but just from the abstract it would seem that this study would suggest the opposite to be true, as my IGF-1 was lower my cognitive function should be higher. Perhaps I am interpreting it incorrectly. [/QUOTE]

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038