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General Health & Fitness
Health & Wellness
Higher IGF-1 and DHEA levels, longer telomere lengths
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<blockquote data-quote="tareload" data-source="post: 143198"><p>One way to "improve" the apparent "statistical significance" when testing models especially logistic (linear) models is to include in the fitting set extra variables, which are correlated, to increase the degrees of freedom in your model and change the residual variance. </p><p></p><p> for more info: <a href="https://stats.stackexchange.com/questions/86269/what-is-the-effect-of-having-correlated-predictors-in-a-multiple-regression-mode" target="_blank">What is the effect of having correlated predictors in a multiple regression model?</a></p><p>However, this is typically frowned upon. I don't have access to their models but the authors don't share in the paper if there was a high correlation between IL-6 and cortisol which has been shown in the literature (see for example):</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673634/" target="_blank">Relationships between inflammatory cytokine and cortisol responses in firefighters exposed to simulated wildfire suppression work and sleep restriction</a></p><p></p><p>If the cortisol score was removed from the A/C imbalance summary, I'm wondering in the odd's ratio for the A/C imbalance summary would still be significant. The odds ratio with 95% CI ain't very strong. Seems like the author's are just picking up the IL-6 effect which makes sense, long-term inflammation bad.</p></blockquote><p></p>
[QUOTE="tareload, post: 143198"] One way to "improve" the apparent "statistical significance" when testing models especially logistic (linear) models is to include in the fitting set extra variables, which are correlated, to increase the degrees of freedom in your model and change the residual variance. for more info: [URL='https://stats.stackexchange.com/questions/86269/what-is-the-effect-of-having-correlated-predictors-in-a-multiple-regression-mode']What is the effect of having correlated predictors in a multiple regression model?[/URL] However, this is typically frowned upon. I don't have access to their models but the authors don't share in the paper if there was a high correlation between IL-6 and cortisol which has been shown in the literature (see for example): [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673634/']Relationships between inflammatory cytokine and cortisol responses in firefighters exposed to simulated wildfire suppression work and sleep restriction[/URL] If the cortisol score was removed from the A/C imbalance summary, I'm wondering in the odd's ratio for the A/C imbalance summary would still be significant. The odds ratio with 95% CI ain't very strong. Seems like the author's are just picking up the IL-6 effect which makes sense, long-term inflammation bad. [/QUOTE]
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General Health & Fitness
Health & Wellness
Higher IGF-1 and DHEA levels, longer telomere lengths
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