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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Higher Estradiol, T and DHT correlated to higher libido in older hypogonadal men than T alone
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<blockquote data-quote="madman" data-source="post: 217301" data-attributes="member: 13851"><p><em><strong>*Circulating testosterone is converted in many peripheral tissues to its two active metabolites, 5α dihydrotestosterone (DHT) and 17β estradiol (E2) </strong></em></p><p><em><strong></strong></em></p><p><em><strong>*In many androgen-responsive tissues, a family of steroid 5α reductase enzymes converts testosterone to DHT, and the aromatase enzyme, a product of the CYP19A1 gene, converts it to E2 </strong></em></p><p><em><strong></strong></em></p><p><em><strong>*Many tissue-specific biologic effects of testosterone are mediated through DHT and E2</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*The rates of conversion of testosterone to DHT and E2 vary among people due to polymorphisms of genes that encode the steroid 5α reductases and the aromatase enzyme as well as other host-specific factors that affect the activity of these enzymes</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*It is not known how the circulating concentrations of testosterone’s metabolites – DHT and E2 – modulate the effects of testosterone on various outcomes and how their circulating levels rank in their contribution to the observed effects of testosterone treatment on physiologic outcomes</strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 217301, member: 13851"] [I][B]*Circulating testosterone is converted in many peripheral tissues to its two active metabolites, 5α dihydrotestosterone (DHT) and 17β estradiol (E2) *In many androgen-responsive tissues, a family of steroid 5α reductase enzymes converts testosterone to DHT, and the aromatase enzyme, a product of the CYP19A1 gene, converts it to E2 *Many tissue-specific biologic effects of testosterone are mediated through DHT and E2 *The rates of conversion of testosterone to DHT and E2 vary among people due to polymorphisms of genes that encode the steroid 5α reductases and the aromatase enzyme as well as other host-specific factors that affect the activity of these enzymes *It is not known how the circulating concentrations of testosterone’s metabolites – DHT and E2 – modulate the effects of testosterone on various outcomes and how their circulating levels rank in their contribution to the observed effects of testosterone treatment on physiologic outcomes[/B][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Higher Estradiol, T and DHT correlated to higher libido in older hypogonadal men than T alone
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