Unfortunately, the article is useless without telling anyone what level of E2 is higher? But it makes it easier to write the abstract if you don’t include numbers. Men aged 70-89 not on TRT are going to have really lower testosterone, and thus lower E2, how low, even if the ratio might change to favor E2, it’s still lower than in men on TRT and with higher T. But you don’t often see the actual data.
If my E2 gets too high I gain water weight and my blood pressure goes up. Too high? I don’t know exactly, maybe >40 pg/ml. I am pretty good at 27 pg/ml.
Nelson’s link.
Can Lowering Estradiol Too Much Accelerate Aging?
Can Lowering Estradiol Too Much Accelerate Aging?
From the data on the link.
(E2 59.3 vs 68.6 pmol/L, p<0.0001; T/S ratio 1.54 vs 1.62, p=0.045), rs10046 C (60.5 vs 68.1 pmol/L, p=0.0005, 1.54 vs 1.62, p=0.035) and rs700518 A (59.9 vs 68.9 pmol/L, p<0.0001, 1.54 vs 1.63, p=0.020).
Such a string of data, but if I read the information and did the conversion on links Nelson provided on E2 and telomere length correctly, then low E2 was 16 pg/ml and high E2 was 18.5 pg/ml. And the T/E ratios were 1.54 Vs 1.62. The higher level of 18.5 pg/ml E2 being better. High E2 in the sense high enough for longer telomere length, not that I think 18.5 pg/ml is really high.
Nelson, am I correct about this? I need an E2 of 18.5 pg/ml to max out telomere length?
