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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
High TT, low FT, high SHBG
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<blockquote data-quote="sammmy" data-source="post: 187986" data-attributes="member: 38594"><p>There is an actual study with human liver cells that shows insulin has nothing to do with it. Liver converts <span style="color: rgb(184, 49, 47)"><strong><u>excess</u></strong></span> glucose/fructose to lipids and that process competitively inhibits the SHBG production in liver - it can't do both at high rates:</p><p></p><p><a href="https://www.eurekalert.org/pub_releases/2007-11/cfr-tms110907.php" target="_blank">Too much sugar turns off gene that controls the effects of sex steroids</a></p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2066187/" target="_blank">Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone–binding globulin gene</a></p><p></p><p>The key point is that excess fast sugar is required so that it is not utilized but converted to fat and I have yet to see an actual intervention study (not observational correlation studies that mean nothing - correlation is not causation) or even anecdotal report that someone with a naturally high SHBG (not high just because of a new keto diet) successfully decreased it to normal range by eating 'clean carbs'.</p></blockquote><p></p>
[QUOTE="sammmy, post: 187986, member: 38594"] There is an actual study with human liver cells that shows insulin has nothing to do with it. Liver converts [COLOR=rgb(184, 49, 47)][B][U]excess[/U][/B][/COLOR] glucose/fructose to lipids and that process competitively inhibits the SHBG production in liver - it can't do both at high rates: [URL='https://www.eurekalert.org/pub_releases/2007-11/cfr-tms110907.php']Too much sugar turns off gene that controls the effects of sex steroids[/URL] [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2066187/']Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone–binding globulin gene[/URL] The key point is that excess fast sugar is required so that it is not utilized but converted to fat and I have yet to see an actual intervention study (not observational correlation studies that mean nothing - correlation is not causation) or even anecdotal report that someone with a naturally high SHBG (not high just because of a new keto diet) successfully decreased it to normal range by eating 'clean carbs'. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
High TT, low FT, high SHBG
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