ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
High Testosterone on only 80mg/week
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 142258" data-attributes="member: 13851"><p><span style="font-size: 22px"><strong>10. Conclusions</strong></span></p><p><strong><span style="color: rgb(184, 49, 47)">In 2015, a large body of evidence indicated an important role for AR CAG polymorphism in conditioning the peripheral effect of testosterone,</span></strong> <strong>even if its contribution warrants further assessment because of the many controversial findings in each androgen-related action.</strong> Of note, <strong><span style="color: rgb(184, 49, 47)">other associations are emerging (e.g., between anogenital distance and the androgen receptor CAG repeat length [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572434/#B106" target="_blank">106</a>]),</span></strong> <strong>but they still need further confirmation.</strong> We believe that the differing results could be justified in light of the difference in the clinical characteristics of the studied subjects, the methodology (transversal/longitudinal studies), and the number of assessed patients. Also, it must be highlighted that so far not all andrological outcomes have been analyzed in depth (e.g., sexual function). Uniformity of methodological evaluation and the study of scarcely considered outcomes are the routes that scientific research will have to take in order to clarify this important issue.</p><p><strong><span style="color: rgb(184, 49, 47)">At present, AR CAG polymorphism is not recommended in the routine setting.</span> However, in the near future, it could become of clinical relevance because of the theoretical possibility of identifying subjects more or less at risk for various disorders and more or less responsive to testosterone treatment.</strong> <strong><span style="color: rgb(184, 49, 47)">In this last case, study of CAG repeat length could allow us to individually tailor testosterone replacement therapy, </span></strong><span style="color: rgb(0, 0, 0)"><strong>as subjects with shorter CAG repeat could need lower doses of testosterone while men with longer repeats could require higher ones.</strong></span></p><p></p><p></p><p></p><p>Polymorphism of the AR and CAG repeat length (short/long), sensitivity of the AR, ones AR density/distribution could very well play a big part.</p><p></p><p>As we know ones SHBG levels have a big impact on what dose of T is needed in order to achieve a healthy FT level.</p></blockquote><p></p>
[QUOTE="madman, post: 142258, member: 13851"] [SIZE=22px][B]10. Conclusions[/B][/SIZE] [B][COLOR=rgb(184, 49, 47)]In 2015, a large body of evidence indicated an important role for AR CAG polymorphism in conditioning the peripheral effect of testosterone,[/COLOR][/B] [B]even if its contribution warrants further assessment because of the many controversial findings in each androgen-related action.[/B] Of note, [B][COLOR=rgb(184, 49, 47)]other associations are emerging (e.g., between anogenital distance and the androgen receptor CAG repeat length [[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572434/#B106']106[/URL]]),[/COLOR][/B] [B]but they still need further confirmation.[/B] We believe that the differing results could be justified in light of the difference in the clinical characteristics of the studied subjects, the methodology (transversal/longitudinal studies), and the number of assessed patients. Also, it must be highlighted that so far not all andrological outcomes have been analyzed in depth (e.g., sexual function). Uniformity of methodological evaluation and the study of scarcely considered outcomes are the routes that scientific research will have to take in order to clarify this important issue. [B][COLOR=rgb(184, 49, 47)]At present, AR CAG polymorphism is not recommended in the routine setting.[/COLOR] However, in the near future, it could become of clinical relevance because of the theoretical possibility of identifying subjects more or less at risk for various disorders and more or less responsive to testosterone treatment.[/B] [B][COLOR=rgb(184, 49, 47)]In this last case, study of CAG repeat length could allow us to individually tailor testosterone replacement therapy, [/COLOR][/B][COLOR=rgb(0, 0, 0)][B]as subjects with shorter CAG repeat could need lower doses of testosterone while men with longer repeats could require higher ones.[/B][/COLOR] Polymorphism of the AR and CAG repeat length (short/long), sensitivity of the AR, ones AR density/distribution could very well play a big part. As we know ones SHBG levels have a big impact on what dose of T is needed in order to achieve a healthy FT level. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
High Testosterone on only 80mg/week
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top