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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
High T and High red blood count Q
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<blockquote data-quote="madman" data-source="post: 141884" data-attributes="member: 13851"><p>The use of exogenous T has an erythropoietic stimulating effect.</p><p></p><p></p><p><span style="font-size: 26px"><strong>Testosterone Induces Erythrocytosis via Increased Erythropoietin and Suppressed Hepcidin: Evidence for a New Erythropoietin/Hemoglobin Set Point</strong></span></p><p></p><p></p><p>Testosterone use in men has increased markedly over the past 15 years—reaching nearly $1.7 billion in prescription sales in 2012—due to numerous factors, including the increased awareness of androgen deficiency syndromes in men and the growing off-label use of testosterone for age-related decline in testosterone levels (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022090/#CIT0001" target="_blank">1</a>). Increased red blood cell mass (erythrocytosis) is the most common adverse event associated with testosterone therapy in clinical practice and in testosterone trials (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022090/#CIT0002" target="_blank">2</a>,<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022090/#CIT0003" target="_blank">3</a>). Thus, understanding the mechanism of testosterone-induced erythrocytosis is important within the context of its safety, especially in older men, who experience greater increments in hemoglobin and hematocrit in response to testosterone administration than young men (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022090/#CIT0004" target="_blank">4</a>).</p><p></p><p></p><p></p><p>[ATTACH=full]7003[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 141884, member: 13851"] The use of exogenous T has an erythropoietic stimulating effect. [SIZE=26px][B]Testosterone Induces Erythrocytosis via Increased Erythropoietin and Suppressed Hepcidin: Evidence for a New Erythropoietin/Hemoglobin Set Point[/B][/SIZE] Testosterone use in men has increased markedly over the past 15 years—reaching nearly $1.7 billion in prescription sales in 2012—due to numerous factors, including the increased awareness of androgen deficiency syndromes in men and the growing off-label use of testosterone for age-related decline in testosterone levels ([URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022090/#CIT0001']1[/URL]). Increased red blood cell mass (erythrocytosis) is the most common adverse event associated with testosterone therapy in clinical practice and in testosterone trials ([URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022090/#CIT0002']2[/URL],[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022090/#CIT0003']3[/URL]). Thus, understanding the mechanism of testosterone-induced erythrocytosis is important within the context of its safety, especially in older men, who experience greater increments in hemoglobin and hematocrit in response to testosterone administration than young men ([URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022090/#CIT0004']4[/URL]). [ATTACH=full]7003[/ATTACH] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
High T and High red blood count Q
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