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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
High SHBG
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<blockquote data-quote="madman" data-source="post: 130018" data-attributes="member: 13851"><p><span style="color: rgb(184, 49, 47)"><strong>Equilibrium dialysis</strong></span> is considered the gold standard <strong>(Endocrine Sciences) </strong>by which all other methods are compared against regarding accuracy of <strong>Free Testosterone</strong></p><p></p><p><strong><a href="https://www.labcorp.com/test-menu/35521/testosterone-free-mass-spectrometry-equilibrium-dialysis-endocrine-sciences" target="_blank">500726: Testosterone, Free, Mass Spectrometry... | LabCorp</a></strong></p><p></p><p></p><p>All other methods whether direct analog immunoassay, Calculated Free T whether <strong>Law of mass action</strong> (Nanjee and Wheeler, Sodergard, Vermeulen), <strong>Empiric formulas</strong> (Ly, Sartorius), FAI (Free Androgen Index) all have there flaws.</p><p></p><p>Out of all the methods I just listed <strong>direct analog immunoassay </strong>is not recommeneded is it is considered inaccurate by the Endocrine Society.</p><p></p><p>When using Equilibrium Dialysis (gold standard) and comparing Calculated Free T Methods <strong>Law of Mass Action (Nanjee and Wheeler, Sodergard, Vermeulen) </strong>although the Vermeulen has been shown to overestimate it is provides the most robust results.....hence it is the one used by most of the Labs (Labcorp).....all Labs in Canada as of the past few years (Canada used to use the direct analog immunoassay which was replaced by the Calculated Free T Law of mass action (Vermeulen method) due to the direct analog immunoassay being inaccurate.</p><p></p><p><a href="https://www.labcorp.com/test-menu/37146/testosterone-free-profile-i" target="_blank">140226: Testosterone Free, Profile I | LabCorp</a></p><p></p><p></p><p><strong>If I had a choice I would be getting the <span style="color: rgb(184, 49, 47)">equilibrium dialysis</span> everytime over the calculated and definitely over the direct analog immunoassay (which is no longer recommended).</strong></p><p></p><p><strong>Especially in cases of altered SHBG levels.</strong></p><p></p><p></p><p></p><p><strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516925/table/T2/" target="_blank">Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials</a></strong></p></blockquote><p></p>
[QUOTE="madman, post: 130018, member: 13851"] [COLOR=rgb(184, 49, 47)][B]Equilibrium dialysis[/B][/COLOR] is considered the gold standard [B](Endocrine Sciences) [/B]by which all other methods are compared against regarding accuracy of [B]Free Testosterone[/B] [B][URL='https://www.labcorp.com/test-menu/35521/testosterone-free-mass-spectrometry-equilibrium-dialysis-endocrine-sciences']500726: Testosterone, Free, Mass Spectrometry... | LabCorp[/URL][/B] All other methods whether direct analog immunoassay, Calculated Free T whether [B]Law of mass action[/B] (Nanjee and Wheeler, Sodergard, Vermeulen), [B]Empiric formulas[/B] (Ly, Sartorius), FAI (Free Androgen Index) all have there flaws. Out of all the methods I just listed [B]direct analog immunoassay [/B]is not recommeneded is it is considered inaccurate by the Endocrine Society. When using Equilibrium Dialysis (gold standard) and comparing Calculated Free T Methods [B]Law of Mass Action (Nanjee and Wheeler, Sodergard, Vermeulen) [/B]although the Vermeulen has been shown to overestimate it is provides the most robust results.....hence it is the one used by most of the Labs (Labcorp).....all Labs in Canada as of the past few years (Canada used to use the direct analog immunoassay which was replaced by the Calculated Free T Law of mass action (Vermeulen method) due to the direct analog immunoassay being inaccurate. [URL='https://www.labcorp.com/test-menu/37146/testosterone-free-profile-i']140226: Testosterone Free, Profile I | LabCorp[/URL] [B]If I had a choice I would be getting the [COLOR=rgb(184, 49, 47)]equilibrium dialysis[/COLOR] everytime over the calculated and definitely over the direct analog immunoassay (which is no longer recommended).[/B] [B]Especially in cases of altered SHBG levels.[/B] [B][URL="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516925/table/T2/"]Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials[/URL][/B] [/QUOTE]
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