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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
high SHBG ? quite high total Test
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<blockquote data-quote="Cataceous" data-source="post: 227101" data-attributes="member: 38109"><p>Yes, lowering SHBG should have little effect on free testosterone. If you lower SHBG in isolation then you should see a drop in total testosterone such that free testosterone is maintained. I've seen no evidence that there's any value in this.</p><p></p><p>Think of exogenous testosterone as contributing to free testosterone, not total. This is because the testosterone is added over a period of time, as is the case with natural production. It's not as though you are instantly adding the entire dose and increasing total testosterone. Instead you are increasing the rate of testosterone entering the body, with free testosterone ending up proportional to this rate.</p><p></p><p>A testosterone nasal gel such as Natesto will increase free testosterone in pulses. It works because it's not too suppressive of natural testosterone production—so you are able to increase the rate of testosterone entering the body, and thus increase free testosterone.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 227101, member: 38109"] Yes, lowering SHBG should have little effect on free testosterone. If you lower SHBG in isolation then you should see a drop in total testosterone such that free testosterone is maintained. I've seen no evidence that there's any value in this. Think of exogenous testosterone as contributing to free testosterone, not total. This is because the testosterone is added over a period of time, as is the case with natural production. It's not as though you are instantly adding the entire dose and increasing total testosterone. Instead you are increasing the rate of testosterone entering the body, with free testosterone ending up proportional to this rate. A testosterone nasal gel such as Natesto will increase free testosterone in pulses. It works because it's not too suppressive of natural testosterone production—so you are able to increase the rate of testosterone entering the body, and thus increase free testosterone. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
high SHBG ? quite high total Test
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