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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
high SHBG ? quite high total Test
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<blockquote data-quote="Cataceous" data-source="post: 217673" data-attributes="member: 38109"><p>With a normal HPTA, the body is regulating testosterone production according to free testosterone, both directly at the hypothalamus and indirectly via estradiol at the hypothalamus and pituitary. However, this is not the only reason for SHBG's lack of influence on free testosterone. The same thing should be observed in guys on TRT who have no endogenous regulation of free testosterone. The reason why SHBG doesn't affect free testosterone at steady state is because testosterone is basically used up in direct proportion to the amount of free testosterone. This in turn implies that free testosterone must be proportional to the rate of testosterone production—or to the dose rate for those on TRT. Therefore free testosterone is essentially independent of SHBG.</p><p></p><p>It is true that if the body were regulating the level of total testosterone then we would have the situation predicted by conventional wisdom, in which forcing down SHBG would raise free testosterone. But this is not the case in normal physiology.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 217673, member: 38109"] With a normal HPTA, the body is regulating testosterone production according to free testosterone, both directly at the hypothalamus and indirectly via estradiol at the hypothalamus and pituitary. However, this is not the only reason for SHBG's lack of influence on free testosterone. The same thing should be observed in guys on TRT who have no endogenous regulation of free testosterone. The reason why SHBG doesn't affect free testosterone at steady state is because testosterone is basically used up in direct proportion to the amount of free testosterone. This in turn implies that free testosterone must be proportional to the rate of testosterone production—or to the dose rate for those on TRT. Therefore free testosterone is essentially independent of SHBG. It is true that if the body were regulating the level of total testosterone then we would have the situation predicted by conventional wisdom, in which forcing down SHBG would raise free testosterone. But this is not the case in normal physiology. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
high SHBG ? quite high total Test
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