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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
High SHBG is Associated with Back Curvature in Aging Men
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<blockquote data-quote="Nelson Vergel" data-source="post: 54260" data-attributes="member: 3"><p>[ATTACH]2690[/ATTACH]</p><p></p><p></p><p>J Bone Miner Res. 2016 Jun 29. doi: 10.1002/jbmr.2901. [Epub ahead of print]</p><p></p><p></p><p><span style="font-size: 10px"><strong>SHBG, Sex Steroids, and Kyphosis in Older Men: the MrOS Study.</strong></span></p><p></p><p>Woods GN1, Huang MH2, Cawthon PM3, Laughlin GA4, Schousboe JT5, McDaniels-Davidson C4, Cauley JA6, Orwoll E7, Barrett-Connor E4, Kado DM4; Osteoporotic Fractures in Men (MrOS) Study Research Group.</p><p></p><p>Author information</p><p></p><p>1University of California, San Diego, La Jolla, CA, USA.</p><p>2David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.</p><p>3California Pacific Medical Center Research Institute and University of California, San Francisco, San Francisco, CA, USA.</p><p>4University of California, San Diego, La Jolla, CA, USA.</p><p>5HealthPartners Institute and Division of Health Policy and Management, University of Minnesota, Minneapolis, MN, USA.</p><p>6Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.</p><p>7Oregon Health Sciences University, Portland, OR, USA.</p><p></p><p>Abstract</p><p></p><p>Accentuated kyphosis is associated with adverse health outcomes, including falls and fractures. Low bone density is a risk factor for hyperkyphosis, and each vertebral fracture adds roughly 4° to forward spine curvature. Sex steroids, in particular low bioavailable estradiol and high sex hormone-binding globulin (SHBG), are associated with bone loss and high SHBG is associated with vertebral fractures in older men. We, therefore, hypothesized that low bioavailable estradiol and high SHBG would be associated with worse kyphosis. To test this hypothesis, we examined the cross-sectional associations between individual bioavailable sex hormones and SHBG with radiographically assessed kyphosis. Participants included 1500 men aged 65 and older from the Osteoporotic Fractures in Men (MrOS) Study, in whom baseline measures of kyphosis and sex hormones were available. Modified Cobb angle of kyphosis, calculated from T4 through T12, was assessed from supine lateral spine radiographs. Serum total estradiol and total testosterone were measured by mass spectrometry, and bioavailable sex steroids were calculated from mass action equations. After adjustment for age and other confounding variables, no association was found between bioavailable estradiol or testosterone and Cobb angle, either when kyphosis was analyzed as a continuous variable or dichotomized into highest versus lower three quartiles. In linear regression models adjusted for age and clinic site, there was a significant association between SHBG and kyphosis (parameter estimate = 0.76 per SD increase, p = 0.01). In the fully adjusted model, this association was weakened and of only borderline statistical significance (parameter estimate = 0.61 per SD, p = 0.05). Logistic models demonstrated similar findings. Although associated with bone loss, we did not demonstrate that low bioavailable estradiol translates into worse kyphosis in older men. High SHBG is associated with bone loss and vertebral fractures. Our results suggest that high SHBG may also be a risk factor for hyperkyphosis.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 54260, member: 3"] [ATTACH=CONFIG]2690[/ATTACH] J Bone Miner Res. 2016 Jun 29. doi: 10.1002/jbmr.2901. [Epub ahead of print] [SIZE=2][B]SHBG, Sex Steroids, and Kyphosis in Older Men: the MrOS Study.[/B][/SIZE] Woods GN1, Huang MH2, Cawthon PM3, Laughlin GA4, Schousboe JT5, McDaniels-Davidson C4, Cauley JA6, Orwoll E7, Barrett-Connor E4, Kado DM4; Osteoporotic Fractures in Men (MrOS) Study Research Group. Author information 1University of California, San Diego, La Jolla, CA, USA. 2David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. 3California Pacific Medical Center Research Institute and University of California, San Francisco, San Francisco, CA, USA. 4University of California, San Diego, La Jolla, CA, USA. 5HealthPartners Institute and Division of Health Policy and Management, University of Minnesota, Minneapolis, MN, USA. 6Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. 7Oregon Health Sciences University, Portland, OR, USA. Abstract Accentuated kyphosis is associated with adverse health outcomes, including falls and fractures. Low bone density is a risk factor for hyperkyphosis, and each vertebral fracture adds roughly 4° to forward spine curvature. Sex steroids, in particular low bioavailable estradiol and high sex hormone-binding globulin (SHBG), are associated with bone loss and high SHBG is associated with vertebral fractures in older men. We, therefore, hypothesized that low bioavailable estradiol and high SHBG would be associated with worse kyphosis. To test this hypothesis, we examined the cross-sectional associations between individual bioavailable sex hormones and SHBG with radiographically assessed kyphosis. Participants included 1500 men aged 65 and older from the Osteoporotic Fractures in Men (MrOS) Study, in whom baseline measures of kyphosis and sex hormones were available. Modified Cobb angle of kyphosis, calculated from T4 through T12, was assessed from supine lateral spine radiographs. Serum total estradiol and total testosterone were measured by mass spectrometry, and bioavailable sex steroids were calculated from mass action equations. After adjustment for age and other confounding variables, no association was found between bioavailable estradiol or testosterone and Cobb angle, either when kyphosis was analyzed as a continuous variable or dichotomized into highest versus lower three quartiles. In linear regression models adjusted for age and clinic site, there was a significant association between SHBG and kyphosis (parameter estimate = 0.76 per SD increase, p = 0.01). In the fully adjusted model, this association was weakened and of only borderline statistical significance (parameter estimate = 0.61 per SD, p = 0.05). Logistic models demonstrated similar findings. Although associated with bone loss, we did not demonstrate that low bioavailable estradiol translates into worse kyphosis in older men. High SHBG is associated with bone loss and vertebral fractures. Our results suggest that high SHBG may also be a risk factor for hyperkyphosis. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
High SHBG is Associated with Back Curvature in Aging Men
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