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SHBG is made in the liver and there's little you can do about it expect play it where it is by adjusting your TRT protocol to compensate. You will need supraphysiological doses of testosterone to get enough free testosterone, something an insurance doctor won't be able to do for you.


The moment your total testosterone goes over the reference ranges, doctors will freak out and lower your dosage. Free testosterone is what matters, in reality if you scored 2500 total testosterone and had the same free testosterone as a man in the high normal ranges say 850, you would be at no greater risk then he.


Total testosterone is in a bound state and biounavailable and in your case should be ignored, free testosterone is your only concern since it's the free portion of the hormone that does all the magic. I've seen countless men beat their heads against a wall trying to lower SHBG with a magical elixir, don't waste your time.


Stop alcohol intake and things that raise SHBG, adjust your TRT protocol. I would concern myself with the long term effects of low free testosterone, heart disease, dementia, alzheimer's and cardiovascular disease.


If you need referrals for doctors that know what needs to be done and won't freak out at supraphysiological doses of testosterone, I can recommend Defy medical who offers telemedicine where I'm a patient.


TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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