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[ATTACH=full]8595[/ATTACH]

Hey! I recently got my Pregnenolone tested and I came back what I think is very high. I am not taking any pregnenolone just testosterone.

I suffer with brain fog and fatigue still after starting TRT and wonder if this has something to do with it.

Any thoughts would be great as I can't find much on Google apart from:

"High pregnenolone levels may be caused by an inherited condition called congenital adrenal hyperplasia (CAH). CAH causes a deficiency or dysfunction in the enzymes required to convert pregnenolone into steroid hormones. This can cause a deficiency of cortisol and an overabundance of male hormones or androgens."

MY CORTISOL

[ATTACH=full]8596[/ATTACH]

Although it states I should have an "overabundance of male hormones" and I have low T (although the above were taken while on TRT)

<blockquote data-quote="Maca" data-source="post: 162493" data-attributes="member: 38216">[ATTACH=full]8595[/ATTACH]Hey! I recently got my Pregnenolone tested and I came back what I think is very high. I am not taking any pregnenolone just testosterone.I suffer with brain fog and fatigue still after starting TRT and wonder if this has something to do with it.Any thoughts would be great as I can&#039;t find much on Google apart from:&quot;High pregnenolone levels may be caused by an inherited condition called congenital adrenal hyperplasia (CAH). CAH causes a deficiency or dysfunction in the enzymes required to convert pregnenolone into steroid hormones. This can cause a deficiency of cortisol and an overabundance of male hormones or androgens.&quot;MY CORTISOL[ATTACH=full]8596[/ATTACH]Although it states I should have an &quot;overabundance of male hormones&quot; and I have low T (although the above were taken while on TRT)</blockquote>

[QUOTE="Maca, post: 162493, member: 38216"] [ATTACH=full]8595[/ATTACH] Hey! I recently got my [B]Pregnenolone [/B]tested and I came back what I think is very high. I am not taking any pregnenolone just testosterone. I suffer with brain fog and fatigue still after starting TRT and wonder if this has something to do with it. Any thoughts would be great as I can't find much on Google apart from: "[B]High pregnenolone levels[/B] may be caused by an inherited condition called congenital adrenal hyperplasia (CAH). CAH causes a deficiency or dysfunction in the enzymes required to convert [B]pregnenolone[/B] into steroid hormones. This can cause a deficiency of cortisol and an overabundance of [B]male[/B] hormones or androgens." [B][U]MY CORTISOL[/U][/B] [ATTACH=full]8596[/ATTACH] Although it states I should have an "overabundance of [B]male[/B] hormones" and I have low T (although the above were taken while on TRT) [/QUOTE]

Verification

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038