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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
High-normal TSH levels tied to all-cause mortality
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<blockquote data-quote="Nelson Vergel" data-source="post: 49022" data-attributes="member: 3"><p>Kosuke Inoue, MD, of the Endocrinology and Diabetes Center, Yokohama Rosai Hospital in Japan, and colleagues evaluated data from National Health and Nutrition Examination Survey III (1988-1994) on 12,584 adults (mean age, 45.4 years; 48.6% men) in the United States to determine the relationship between low-normal thyroid function and all-cause or cause-specific mortalities. Follow-up was conducted for a median of 19.1 years.</p><p></p><p><strong>Participants were divided into groups based on their TSH concentrations: 0.39 mIU/L to 1.15 mIU/L (low-normal TSH group), 1.16 mIU/L to 1.89 mIU/L (medium-normal TSH group) and 1.9 mIU/L to 4.6 mIU/L (high-normal TSH group).</strong></p><p></p><p>Through follow-up, there were 3,395 all-cause deaths, including 1,048 CV deaths, 730 cancer deaths and 1,617 deaths from other causes.</p><p></p><p>Compared with the medium-normal TSH group, the high-normal TSH group (HR = 1.27; 95% CI, 1.1-1.47) and the low-normal TSH group (HR = 1.17; 95% CI, 1.02-1.35) had increased risk for all-cause death. The high-normal TSH group had a higher risk for CV death (HR = 1.3; 95% CI, 1.02-1.67) or cancer death (HR = 1.43; 95% CI, 1.01-2.01) compared with the other two groups.</p><p></p><p>The risk for all-cause mortality was significantly higher for men in the high-normal TSH group (HR = 1.29; 95% CI, 1.06-1.58) and men in the low-normal TSH group (HR = 1.32; 95% CI, 1.08-1.61) compared with men in the medium-normal TSH group. The risk for all-cause mortality was higher among women in the high-normal TSH group compared with women in the other two groups (HR = 1.24; 95% CI, 1.05-1.46).</p><p></p><p>In participants younger than 60 years, the risk for all-cause mortality was higher in the high-normal TSH group (HR = 1.49; 95% CI, 1.19-1.86) and the low-normal TSH group (HR = 1.29; 95% CI, 1.03-1.6) compared with the medium-normal TSH group. The high-normal TSH group had a higher prevalence of metabolic syndrome compared with the medium-normal TSH group (OR = 1.22; 95% CI, 0.96-1.55).</p><p></p><p><a href="http://www.healio.com/endocrinology/thyroid/news/in-the-journals/%7B27cb507c-e12d-405c-86a9-569c23dc1bad%7D/high-normal-tsh-levels-tied-to-all-cause-mortality" target="_blank">http://www.healio.com/endocrinology/thyroid/news/in-the-journals/{27cb507c-e12d-405c-86a9-569c23dc1bad}/high-normal-tsh-levels-tied-to-all-cause-mortality</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 49022, member: 3"] Kosuke Inoue, MD, of the Endocrinology and Diabetes Center, Yokohama Rosai Hospital in Japan, and colleagues evaluated data from National Health and Nutrition Examination Survey III (1988-1994) on 12,584 adults (mean age, 45.4 years; 48.6% men) in the United States to determine the relationship between low-normal thyroid function and all-cause or cause-specific mortalities. Follow-up was conducted for a median of 19.1 years. [B]Participants were divided into groups based on their TSH concentrations: 0.39 mIU/L to 1.15 mIU/L (low-normal TSH group), 1.16 mIU/L to 1.89 mIU/L (medium-normal TSH group) and 1.9 mIU/L to 4.6 mIU/L (high-normal TSH group).[/B] Through follow-up, there were 3,395 all-cause deaths, including 1,048 CV deaths, 730 cancer deaths and 1,617 deaths from other causes. Compared with the medium-normal TSH group, the high-normal TSH group (HR = 1.27; 95% CI, 1.1-1.47) and the low-normal TSH group (HR = 1.17; 95% CI, 1.02-1.35) had increased risk for all-cause death. The high-normal TSH group had a higher risk for CV death (HR = 1.3; 95% CI, 1.02-1.67) or cancer death (HR = 1.43; 95% CI, 1.01-2.01) compared with the other two groups. The risk for all-cause mortality was significantly higher for men in the high-normal TSH group (HR = 1.29; 95% CI, 1.06-1.58) and men in the low-normal TSH group (HR = 1.32; 95% CI, 1.08-1.61) compared with men in the medium-normal TSH group. The risk for all-cause mortality was higher among women in the high-normal TSH group compared with women in the other two groups (HR = 1.24; 95% CI, 1.05-1.46). In participants younger than 60 years, the risk for all-cause mortality was higher in the high-normal TSH group (HR = 1.49; 95% CI, 1.19-1.86) and the low-normal TSH group (HR = 1.29; 95% CI, 1.03-1.6) compared with the medium-normal TSH group. The high-normal TSH group had a higher prevalence of metabolic syndrome compared with the medium-normal TSH group (OR = 1.22; 95% CI, 0.96-1.55). [url]http://www.healio.com/endocrinology/thyroid/news/in-the-journals/%7B27cb507c-e12d-405c-86a9-569c23dc1bad%7D/high-normal-tsh-levels-tied-to-all-cause-mortality[/url] [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
High-normal TSH levels tied to all-cause mortality
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