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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
High levels on testosterone gel with AI
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<blockquote data-quote="Cataceous" data-source="post: 189319" data-attributes="member: 38109"><p>For better or worse, injections make it easy to deliver a lot of testosterone quickly. All too often guys measure trough serum testosterone at 3.5 or 7 days post-injection and titrate doses based on that number. This neglects that peaks may be as much as 50% and 200% higher, respectively.</p><p></p><p>My impression from some of [USER=13851]@madman[/USER]'s posts is that while physiological testosterone levels can improve muscle condition compared to a hypogonadal state, significant gains require much higher levels.</p><p></p><p>Free testosterone is largely a function of total testosterone, SHBG and albumin. The <a href="https://tru-t.org" target="_blank">Tru-T calculation</a> predicts it from these parameters. It can also be measured using one of the accurate methods, such as equilibrium dialysis. The method of testosterone delivery doesn't matter unless high post-injection peaks are not accounted for. Testosterone cypionate can be dosed EOD or daily to greatly smooth out serum testosterone and avoid large swings in free testosterone, DHT and estradiol.</p><p></p><p>Your serum testosterone level is probably plenty high, but I would have concerns about continuing with that much anastrozole. The topical use of testosterone may be creating a lot of DHT, which has anti-estrogenic properties of its own. You should monitor SHBG and lipids, which hopefully act as canaries in the coal mine, warning about an imbalance that is otherwise not causing symptoms.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 189319, member: 38109"] For better or worse, injections make it easy to deliver a lot of testosterone quickly. All too often guys measure trough serum testosterone at 3.5 or 7 days post-injection and titrate doses based on that number. This neglects that peaks may be as much as 50% and 200% higher, respectively. My impression from some of [USER=13851]@madman[/USER]'s posts is that while physiological testosterone levels can improve muscle condition compared to a hypogonadal state, significant gains require much higher levels. Free testosterone is largely a function of total testosterone, SHBG and albumin. The [URL='https://tru-t.org']Tru-T calculation[/URL] predicts it from these parameters. It can also be measured using one of the accurate methods, such as equilibrium dialysis. The method of testosterone delivery doesn't matter unless high post-injection peaks are not accounted for. Testosterone cypionate can be dosed EOD or daily to greatly smooth out serum testosterone and avoid large swings in free testosterone, DHT and estradiol. Your serum testosterone level is probably plenty high, but I would have concerns about continuing with that much anastrozole. The topical use of testosterone may be creating a lot of DHT, which has anti-estrogenic properties of its own. You should monitor SHBG and lipids, which hopefully act as canaries in the coal mine, warning about an imbalance that is otherwise not causing symptoms. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
High levels on testosterone gel with AI
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