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Testosterone Replacement, Low T, HCG, & Beyond
Prostate Related Issues
High levels of two hormones in the blood raise prostate cancer risk
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<blockquote data-quote="madman" data-source="post: 162365" data-attributes="member: 13851"><p>Key points to keep in mind:</p><p></p><p><strong>“We were interested in studying the levels of two hormones circulating in the blood because previous research<span style="color: rgb(184, 49, 47)"> suggests they could be linked with prostate cancer </span>and because these are factors that could potentially be altered in an attempt to reduce prostate cancer risk.” </strong></p><p></p><p><strong>Dr Travis said: “This type of study <span style="color: rgb(184, 49, 47)">can ’t tell us why these factors are linked,</span> but we know that testosterone plays a role in the normal growth and function of the prostate and that IGF-I has a role in stimulating the growth of cells in our bodies.” </strong></p><p></p><p><strong>“What this research does tell us is that these two hormones <span style="color: rgb(184, 49, 47)">could be a mechanism that links </span>things like diet, lifestyle and body size with the risk of prostate cancer. This takes us a step closer to strategies for preventing the disease.”</strong></p><p></p><p><strong>Dr Travis and Ms Watts <span style="color: rgb(184, 49, 47)">will continue examining the data from this study</span> <span style="color: rgb(184, 49, 47)">to confirm their findings.</span> In the future, they also plan to home in on risk factors for the most aggressive types of prostate cancer.</strong></p><p></p><p></p><p></p><p></p><p>We do not have the full study to pick apart.....no point in jumping to conclusions!</p><p></p><p></p><p>As Nelson stated.....<span style="color: rgb(184, 49, 47)">"If you want to see a review of all studies related to prostate cancer, spend a little time to educate yourself with this info"</span></p><p></p><p>There are numerous threads on the forum regarding prostate cancer and testosterone:</p><p></p><p></p><p><a href="https://www.excelmale.com/forum/threads/safety-of-testosterone-therapy-in-men-with-prostate-cancer.19588/#post-158777" target="_blank">Safety of testosterone therapy in men with prostate cancer</a></p><p></p><p><a href="https://www.excelmale.com/forum/threads/testosterone-therapy-in-men-with-advanced-prostate-cancer-posted-by-abraham-morgentaler-md-facs-jun-2019.19041/#post-152153" target="_blank">Testosterone Therapy in Men with Advanced Prostate Cancer Posted by Abraham Morgentaler, MD, FACS | Jun 2019</a></p><p></p><p><a href="https://www.excelmale.com/forum/threads/testosterone-slows-prostate-cancer-recurrence-in-low-risk-patients.18070/#post-142086" target="_blank">Testosterone slows prostate cancer recurrence in low-risk patients</a></p><p></p><p><a href="https://www.excelmale.com/forum/threads/testosterone-testosterone-therapy-and-prostate-cancer.17369/#post-133936" target="_blank">Testosterone, testosterone therapy and prostate cancer</a></p><p></p><p><a href="https://www.excelmale.com/forum/threads/eau-2019-low-free-testosterone-is-an-independent-risk-factor-for-high-grade-prostate-cancer.18069/#post-142082" target="_blank">EAU 2019: Low Free Testosterone is an Independent Risk Factor for High Grade Prostate Cancer</a></p><p></p><p><a href="https://www.excelmale.com/forum/threads/sex-steroids-in-serum-and-prostatic-tissue-of-human-cancerous-prostate-sterkproser-trial.16756/#post-127368" target="_blank">Sex steroids in serum and prostatic tissue of human cancerous prostate (STERKPROSER trial)</a></p><p></p><p><a href="https://www.excelmale.com/forum/threads/role-of-androgen-receptor-in-prostate-cancer-a-review.16301/#post-122739" target="_blank">Role of Androgen Receptor in Prostate Cancer: A Review</a></p><p></p><p><a href="https://www.excelmale.com/forum/threads/a-novel-model-to-predict-positive-prostate-biopsy-with-low-free-testosterone-percent.15567/#post-115421" target="_blank">A novel model to predict positive prostate biopsy with low free testosterone percent</a></p><p></p><p><a href="https://www.excelmale.com/forum/threads/lower-circulating-androgens-are-associated-with-overall-cancer-risk-and-prostate-cancer-risk-in-men-aged-25%E2%80%9384-years-from-the-busselton-health-study.16163/#post-121477" target="_blank">Lower Circulating Androgens Are Associated with Overall Cancer Risk and Prostate Cancer Risk in Men Aged 25–84 Years from the Busselton Health Study</a></p><p></p><p><a href="https://www.excelmale.com/forum/threads/case-deliberations-to-treat-or-not-to-treat-with-testosterone-therapy.18925/#post-150792" target="_blank">Case deliberations: To treat or not to treat with testosterone therapy?</a> </p><p></p><p></p><p></p><p>Also keep in mind that regarding FT.....the most accurate testing method is Equilibrium Dialysis which is considered the gold standard or Ultrafiltration (next best) which they did not use.</p><p></p><p></p><p></p><p><strong>The researchers studied <span style="color: rgb(184, 49, 47)">200,452 men</span> who are part of the UK Biobank project. <span style="color: rgb(26, 188, 156)">All were free of cancer when they joined the study and were not taking any hormone therapy.</span></strong></p><p></p><p><strong>The men gave blood samples that were tested for their levels of testosterone and a growth hormone called insulin-like growth factor-I (IGF-I).</strong> <strong>The researchers <span style="color: rgb(184, 49, 47)">calculated levels of free testosterone </span>– testosterone that is circulating in the blood and not bound to any other molecule and can therefore have an effect in the body. </strong><span style="color: rgb(26, 188, 156)"><strong>A subset of 9,000 of men gave a second blood sample at a later date, to help the researchers account for natural fluctuations in hormone levels.</strong></span></p><p></p><p><strong>The men were followed for <span style="color: rgb(26, 188, 156)">an average of six to seven years to see if they went on to develop prostate cancer. </span>Within the group, there were <span style="color: rgb(184, 49, 47)">5,412 cases</span> and <span style="color: rgb(184, 49, 47)">296 deaths from the disease.</span></strong></p><p></p><p><strong>The researchers found that <span style="color: rgb(26, 188, 156)">men with higher concentrations of the two hormones in their blood </span>were more likely to be diagnosed with prostate cancer.</strong></p><p></p><p></p><p></p><p>They calculated FT most likely using the flawed and outdated linear law-of-mass action model <strong><span style="color: rgb(26, 188, 156)">(Vermeulen equation)</span></strong></p><p></p><p></p><p><strong>About <span style="color: rgb(184, 49, 47)">TruT™</span></strong></p><p></p><p><strong>Current problems with accurate free testosterone determination</strong></p><p></p><p><span style="color: rgb(184, 49, 47)">Current methods for measuring free testosterone (fT) are technically challenging and not accurate.</span> The widely used direct immunoassay and tracer analog techniques for measuring fT have been shown to be inaccurate. Equilibrium dialysis, the reference method against which other methods are compared, is labor-intensive and cumbersome, and therefore has had limited clinical adoption. As an alternative, free testosterone can be computed from the <em>total</em> testosterone, SHBG, and albumin concentrations. Recently, Endocrine Society’s Expert Panel acknowledged the experimental problems in fT measurements and concluded that "...the calculation of free testosterone is the most useful estimate of free testosterone in plasma...<strong><span style="color: rgb(184, 49, 47)">" However, we have demonstrated that</span> <span style="color: rgb(26, 188, 156)">even the calculated fT values derived from the prevailing equations, based on linear law-of-mass action models or empiric equations, differ systematically from free testosterone measured by </span><span style="color: rgb(184, 49, 47)">equilibrium dialysis</span> <span style="color: rgb(26, 188, 156)">by as much as 40%.</span></strong></p></blockquote><p></p>
[QUOTE="madman, post: 162365, member: 13851"] Key points to keep in mind: [B]“We were interested in studying the levels of two hormones circulating in the blood because previous research[COLOR=rgb(184, 49, 47)] suggests they could be linked with prostate cancer [/COLOR]and because these are factors that could potentially be altered in an attempt to reduce prostate cancer risk.” [/B] [B]Dr Travis said: “This type of study [COLOR=rgb(184, 49, 47)]can ’t tell us why these factors are linked,[/COLOR] but we know that testosterone plays a role in the normal growth and function of the prostate and that IGF-I has a role in stimulating the growth of cells in our bodies.” [/B] [B]“What this research does tell us is that these two hormones [COLOR=rgb(184, 49, 47)]could be a mechanism that links [/COLOR]things like diet, lifestyle and body size with the risk of prostate cancer. This takes us a step closer to strategies for preventing the disease.”[/B] [B]Dr Travis and Ms Watts [COLOR=rgb(184, 49, 47)]will continue examining the data from this study[/COLOR] [COLOR=rgb(184, 49, 47)]to confirm their findings.[/COLOR] In the future, they also plan to home in on risk factors for the most aggressive types of prostate cancer.[/B] We do not have the full study to pick apart.....no point in jumping to conclusions! As Nelson stated.....[COLOR=rgb(184, 49, 47)]"If you want to see a review of all studies related to prostate cancer, spend a little time to educate yourself with this info"[/COLOR] There are numerous threads on the forum regarding prostate cancer and testosterone: [URL='https://www.excelmale.com/forum/threads/safety-of-testosterone-therapy-in-men-with-prostate-cancer.19588/#post-158777']Safety of testosterone therapy in men with prostate cancer[/URL] [URL='https://www.excelmale.com/forum/threads/testosterone-therapy-in-men-with-advanced-prostate-cancer-posted-by-abraham-morgentaler-md-facs-jun-2019.19041/#post-152153']Testosterone Therapy in Men with Advanced Prostate Cancer Posted by Abraham Morgentaler, MD, FACS | Jun 2019[/URL] [URL='https://www.excelmale.com/forum/threads/testosterone-slows-prostate-cancer-recurrence-in-low-risk-patients.18070/#post-142086']Testosterone slows prostate cancer recurrence in low-risk patients[/URL] [URL='https://www.excelmale.com/forum/threads/testosterone-testosterone-therapy-and-prostate-cancer.17369/#post-133936']Testosterone, testosterone therapy and prostate cancer[/URL] [URL='https://www.excelmale.com/forum/threads/eau-2019-low-free-testosterone-is-an-independent-risk-factor-for-high-grade-prostate-cancer.18069/#post-142082']EAU 2019: Low Free Testosterone is an Independent Risk Factor for High Grade Prostate Cancer[/URL] [URL='https://www.excelmale.com/forum/threads/sex-steroids-in-serum-and-prostatic-tissue-of-human-cancerous-prostate-sterkproser-trial.16756/#post-127368']Sex steroids in serum and prostatic tissue of human cancerous prostate (STERKPROSER trial)[/URL] [URL='https://www.excelmale.com/forum/threads/role-of-androgen-receptor-in-prostate-cancer-a-review.16301/#post-122739']Role of Androgen Receptor in Prostate Cancer: A Review[/URL] [URL='https://www.excelmale.com/forum/threads/a-novel-model-to-predict-positive-prostate-biopsy-with-low-free-testosterone-percent.15567/#post-115421']A novel model to predict positive prostate biopsy with low free testosterone percent[/URL] [URL='https://www.excelmale.com/forum/threads/lower-circulating-androgens-are-associated-with-overall-cancer-risk-and-prostate-cancer-risk-in-men-aged-25%E2%80%9384-years-from-the-busselton-health-study.16163/#post-121477']Lower Circulating Androgens Are Associated with Overall Cancer Risk and Prostate Cancer Risk in Men Aged 25–84 Years from the Busselton Health Study[/URL] [URL="https://www.excelmale.com/forum/threads/case-deliberations-to-treat-or-not-to-treat-with-testosterone-therapy.18925/#post-150792"]Case deliberations: To treat or not to treat with testosterone therapy?[/URL] Also keep in mind that regarding FT.....the most accurate testing method is Equilibrium Dialysis which is considered the gold standard or Ultrafiltration (next best) which they did not use. [B]The researchers studied [COLOR=rgb(184, 49, 47)]200,452 men[/COLOR] who are part of the UK Biobank project. [COLOR=rgb(26, 188, 156)]All were free of cancer when they joined the study and were not taking any hormone therapy.[/COLOR][/B] [B]The men gave blood samples that were tested for their levels of testosterone and a growth hormone called insulin-like growth factor-I (IGF-I).[/B] [B]The researchers [COLOR=rgb(184, 49, 47)]calculated levels of free testosterone [/COLOR]– testosterone that is circulating in the blood and not bound to any other molecule and can therefore have an effect in the body. [/B][COLOR=rgb(26, 188, 156)][B]A subset of 9,000 of men gave a second blood sample at a later date, to help the researchers account for natural fluctuations in hormone levels.[/B][/COLOR] [B]The men were followed for [COLOR=rgb(26, 188, 156)]an average of six to seven years to see if they went on to develop prostate cancer. [/COLOR]Within the group, there were [COLOR=rgb(184, 49, 47)]5,412 cases[/COLOR] and [COLOR=rgb(184, 49, 47)]296 deaths from the disease.[/COLOR][/B] [B]The researchers found that [COLOR=rgb(26, 188, 156)]men with higher concentrations of the two hormones in their blood [/COLOR]were more likely to be diagnosed with prostate cancer.[/B] They calculated FT most likely using the flawed and outdated linear law-of-mass action model [B][COLOR=rgb(26, 188, 156)](Vermeulen equation)[/COLOR][/B] [B]About [COLOR=rgb(184, 49, 47)]TruT™[/COLOR][/B] [B]Current problems with accurate free testosterone determination[/B] [COLOR=rgb(184, 49, 47)]Current methods for measuring free testosterone (fT) are technically challenging and not accurate.[/COLOR] The widely used direct immunoassay and tracer analog techniques for measuring fT have been shown to be inaccurate. Equilibrium dialysis, the reference method against which other methods are compared, is labor-intensive and cumbersome, and therefore has had limited clinical adoption. As an alternative, free testosterone can be computed from the [I]total[/I] testosterone, SHBG, and albumin concentrations. Recently, Endocrine Society’s Expert Panel acknowledged the experimental problems in fT measurements and concluded that "...the calculation of free testosterone is the most useful estimate of free testosterone in plasma...[B][COLOR=rgb(184, 49, 47)]" However, we have demonstrated that[/COLOR] [COLOR=rgb(26, 188, 156)]even the calculated fT values derived from the prevailing equations, based on linear law-of-mass action models or empiric equations, differ systematically from free testosterone measured by [/COLOR][COLOR=rgb(184, 49, 47)]equilibrium dialysis[/COLOR] [COLOR=rgb(26, 188, 156)]by as much as 40%.[/COLOR][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Prostate Related Issues
High levels of two hormones in the blood raise prostate cancer risk
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